| |
Sham (n = 8)
|
MI + Veh (n = 8)
|
MI + Ram (n = 8)
|
|---|
|
Echocardiography data
| | |
|
LVIDs (cm)
|
0.43 ± 0.02
|
0.89 ± 0.02 ***
|
0.77 ± 0.02 ###
|
|
LVIDd (cm)
|
0.69 ± 0.01
|
0.99 ± 0.01 ***
|
0.94 ± 0.02 #
|
|
%FS
|
38.6 ± 2.1
|
9.8 ± 1.3 ***
|
17.2 ± 2.0 #
|
|
Hemodynamic data
| | |
|
CAP (mmHg)
|
127.6 ± 1.7
|
117.1 ± 5.1
|
104.3 ± 3.4
|
|
SBP (mmHg)
|
146.9 ± 4.0
|
132.5 ± 4.4
|
120.1 ± 2.5 #
|
|
DBP (mmHg)
|
106.8 ± 3.3
|
102.0 ± 6.8
|
88.9 ± 4.4
|
|
HR (beats/min)
|
348 ± 7
|
355 ± 29
|
352 ± 16
|
|
LVEDP (mmHg)
|
2.8 ± 0.7
|
9.1 ± 1.1 ***
|
5.5 ± 0.8 #
|
|
dP/dt
max
(mmHg/s)
|
5898 ± 165
|
4819 ± 274 *
|
5156 ± 115
|
|
dP/dt
min
(mmHg/s)
|
−5851 ± 161
|
−4637 ± 329 **
|
−5021 ± 159
|
- LVIDs – left ventricular internal diameter in systole; LVIDd – left ventricular internal diameter in diastole; %FS – percentage fractional shortening; CAP – central aortic pressure; SBP – systolic blood pressure; DBP – diastolic blood pressure; HR – heart rate; LVEDP – left ventricular end diastolic blood pressure; dP/dtmax – rate of left ventricular pressure rise; dP/dtmin – rate of left ventricular pressure fall.
- Data are expressed as mean ± SEM; * P < 0.05, ** P < 0.01, *** P < 0.001 compared to sham animals; # P < 0.05, ### P < 0.001 compared to MI + Veh animals.
