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  1. Research

    Novel paradigm for immunotherapy of ovarian cancer by engaging prophylactic immunity against hepatitis B virus

    Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Clinical and Translational Medicine 2016 5:44

    Published on: 30 November 2016

  2. Review

    Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation

    The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Clinical and Translational Medicine 2016 5:41

    Published on: 20 October 2016

  3. Research

    Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases

    We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Clinical and Translational Medicine 2016 5:40

    Published on: 20 October 2016

  4. Research

    Serum levels of S100A6 are unaltered in patients with resectable cholangiocarcinoma

    Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Clinical and Translational Medicine 2016 5:39

    Published on: 27 September 2016

  5. Research

    Pharmacokinetics of oseltamivir in infants under the age of 1 year

    Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Clinical and Translational Medicine 2016 5:37

    Published on: 5 September 2016

  6. Research

    JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

    Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Clinical and Translational Medicine 2016 5:36

    Published on: 2 September 2016

  7. Meeting abstracts

    A One Health overview, facilitating advances in comparative medicine and translational research

    A1 One health advances and successes in comparative medicine and translational research

    Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Clinical and Translational Medicine 2016 5(Suppl 1):26

    Published on: 23 August 2016

    This article is part of a Supplement: Volume 5 Supplement 1

  8. Research

    A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C

    High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Clinical and Translational Medicine 2016 5:33

    Published on: 18 August 2016

  9. Review

    Therapeutic use of stem cells for cardiovascular disease

    Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Whitney Faiella and Rony Atoui

    Clinical and Translational Medicine 2016 5:34

    Published on: 18 August 2016

  10. Review

    Creatine kinase in ischemic and inflammatory disorders

    The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Clinical and Translational Medicine 2016 5:31

    Published on: 15 August 2016

  11. Erratum

    Erratum to: Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

    Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Clinical and Translational Medicine 2016 5:30

    Published on: 12 August 2016

    The original article was published in Clinical and Translational Medicine 2016 5:23

  12. Review

    Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis

    Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ine...

    John Burke, Monte Hunter, Ravindra Kolhe, Carlos Isales, Mark Hamrick and Sadanand Fulzele

    Clinical and Translational Medicine 2016 5:27

    Published on: 10 August 2016

  13. Review

    Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer?

    The major problem with cancer progression and anti-cancer therapy is the inherent ability of cancer cells to migrate and establish distant metastases. This ability to metastasize correlates with the presence i...

    Mariusz Z. Ratajczak, Malwina Suszynska and Magda Kucia

    Clinical and Translational Medicine 2016 5:28

    Published on: 10 August 2016

  14. Review

    Clinical significance of T cell metabolic reprogramming in cancer

    Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known ...

    Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver and Vassiliki A. Boussiotis

    Clinical and Translational Medicine 2016 5:29

    Published on: 10 August 2016

  15. Research

    Integrated information for integrated care in the general practice setting in Italy: using social network analysis to go beyond the diagnosis of frailty in the elderly

    Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ...

    Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro

    Clinical and Translational Medicine 2016 5:24

    Published on: 27 July 2016

  16. Perspective

    Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

    This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r...

    Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Clinical and Translational Medicine 2016 5:23

    Published on: 25 July 2016

    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:30

  17. Review

    Mitochondria, cholesterol and cancer cell metabolism

    Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi...

    Vicent Ribas, Carmen García-Ruiz and José C. Fernández-Checa

    Clinical and Translational Medicine 2016 5:22

    Published on: 25 July 2016

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