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  1. Research

    Pharmacokinetics of oseltamivir in infants under the age of 1 year

    Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Clinical and Translational Medicine 2016 5:37

    Published on: 5 September 2016

  2. Research

    JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

    Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Clinical and Translational Medicine 2016 5:36

    Published on: 2 September 2016

  3. Meeting abstracts

    A One Health overview, facilitating advances in comparative medicine and translational research

    A1 One health advances and successes in comparative medicine and translational research

    Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Clinical and Translational Medicine 2016 5(Suppl 1):26

    Published on: 23 August 2016

    This article is part of a Supplement: Volume 5 Supplement 1

  4. Research

    A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C

    High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Clinical and Translational Medicine 2016 5:33

    Published on: 18 August 2016

  5. Review

    Therapeutic use of stem cells for cardiovascular disease

    Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Whitney Faiella and Rony Atoui

    Clinical and Translational Medicine 2016 5:34

    Published on: 18 August 2016

  6. Review

    Creatine kinase in ischemic and inflammatory disorders

    The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Clinical and Translational Medicine 2016 5:31

    Published on: 15 August 2016

  7. Erratum

    Erratum to: Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

    Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Clinical and Translational Medicine 2016 5:30

    Published on: 12 August 2016

    The original article was published in Clinical and Translational Medicine 2016 5:23

  8. Review

    Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis

    Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ine...

    John Burke, Monte Hunter, Ravindra Kolhe, Carlos Isales, Mark Hamrick and Sadanand Fulzele

    Clinical and Translational Medicine 2016 5:27

    Published on: 10 August 2016

  9. Review

    Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer?

    The major problem with cancer progression and anti-cancer therapy is the inherent ability of cancer cells to migrate and establish distant metastases. This ability to metastasize correlates with the presence i...

    Mariusz Z. Ratajczak, Malwina Suszynska and Magda Kucia

    Clinical and Translational Medicine 2016 5:28

    Published on: 10 August 2016

  10. Review

    Clinical significance of T cell metabolic reprogramming in cancer

    Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known ...

    Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver and Vassiliki A. Boussiotis

    Clinical and Translational Medicine 2016 5:29

    Published on: 10 August 2016

  11. Research

    Integrated information for integrated care in the general practice setting in Italy: using social network analysis to go beyond the diagnosis of frailty in the elderly

    Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ...

    Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro

    Clinical and Translational Medicine 2016 5:24

    Published on: 27 July 2016

  12. Perspective

    Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

    This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r...

    Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Clinical and Translational Medicine 2016 5:23

    Published on: 25 July 2016

    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:30

  13. Review

    Mitochondria, cholesterol and cancer cell metabolism

    Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi...

    Vicent Ribas, Carmen García-Ruiz and José C. Fernández-Checa

    Clinical and Translational Medicine 2016 5:22

    Published on: 25 July 2016

  14. Research

    Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong

    Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Clinical and Translational Medicine 2016 5:18

    Published on: 16 May 2016

  15. Research

    Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

    Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition...

    Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell

    Clinical and Translational Medicine 2016 5:17

    Published on: 13 May 2016

  16. Review

    Mitochondrial transplantation for therapeutic use

    Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst...

    James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan

    Clinical and Translational Medicine 2016 5:16

    Published on: 29 April 2016

  17. Research

    Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease

    The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant red...

    Gift Dineo Pule, Shaheen Mowla, Nicolas Novitzky and Ambroise Wonkam

    Clinical and Translational Medicine 2016 5:15

    Published on: 7 April 2016

  18. Review

    Energy metabolic dysfunction as a carcinogenic factor in cancer cells

    Cancer, as a leading cause of death, has attracted enormous public attention. Reprogramming of cellular energy metabolism is deemed to be one of the principal hallmarks of cancer. In this article, we reviewed ...

    Yongyan Sun, Zhenhua Shi, Huiyong Lian and Peng Cai

    Clinical and Translational Medicine 2016 5:14

    Published on: 6 April 2016

  19. Review

    Genomics, microRNA, epigenetics, and proteomics for future diagnosis, treatment and monitoring response in upper GI cancers

    One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Clinical and Translational Medicine 2016 5:13

    Published on: 6 April 2016

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