Pros and cons of mouse models for studying osteoarthritis

Clinical and Translational Medicine

Table 2 This table indicates the appropriate uses for each type of murine OA model. An X indicates that a model is appropriate for a specific type of study

	OA pathophysiology	OA progression	OA therapies	Pain behavior	Post-traumatic OA studies	References
Naturally occurring	X	X	X	X		[9,10,11]
Genetically modified	X	X	X	X		[12,13,14,15,16,17,18,19,20,21,22,23,24]
Surgically induced (all)	X	X	X	X	X	[25,26,27,28,29,30]
Chemically induced (all)				X		[31,32,33,34,35,36,37,38,39]
Non-invasive induction	X	X	X	X	X	[40,41,42,43,44,45,46,47,48,49,50,51,52]