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Clinical and Translational Medicine
Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: Extracellular vesicles: how they interact with endothelium, potentially contributing to metastatic cancer cell implants

Fig. 1

The normal cell membrane is an asymmetrical bilayered structure with phosphatidylserine- and phosphatidyl-ethanolamine-enriched cytosolic layers, maintained by flippase, floppase and scramblase. As extracellular vesicles are formed, the flippases is inactivated while floppase and scramblase are activated, leading to reversal of the normal asymmetry, creating an outward facing phosphatidylserine enriched layer

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