From: Biofluid lipidome: a source for potential diagnostic biomarkers
S no | Biological fluid | Lipid class | Lipid species | Disease | Refs |
---|---|---|---|---|---|
1 | Serum | Glycerophosphoserine (PS) | PS(O-16:0/20:2) | Hepatocellular carcinoma (HCC) | [62] |
PS(O-18:0/22:6) | Â | Â | |||
PS(O-18:0/22:4) | Â | Â | |||
Glycerophosphocholines (PC) | (PC(15:0/20:3)) | Â | Â | ||
Gycerophosophoinositols (PI) | PI(O-16:0/20:1) | Â | Â | ||
Phospholipids/sphingomyelin (SM) | SM 16:0/1 | Lung tumor | [64] | ||
LPC 18:1, 20:3, 20:4 and 22:6 | Â | Â | |||
Phospholipids | PC 38:5, 40:3 and 42:2 | Prostate cancer | Â | ||
PC 36:9 | Â | ||||
FA 22:3 | Â | Â | |||
2 | Plasma |  | d18:1/14:0—SM | Gaucher’s disease | [63] |
3Â | Urine | Triglycerides (TG) | Â | Nephrotic syndrome | [80] |
Phosphatidylcholines (PC) | Â | Â | Â | ||
Phosphatidylethanolamine (PE) | Â | Â | Â | ||
Phosphatidylserine (PS) | Â | Â | Â | ||
Phosphatidylserine (PS) | PS 18:1/18:1 and 18:2/18:0 | Breast cancer | [84] | ||
Phosphoinositol (PI) | Â | Â | Â | ||
Phosphatidylserine (PS) | PS 18:0/18:1 | Prostate cancer | [85] | ||
PS 16:0/22:6 | Â | Â | |||
PS 18:1/18:0 | Â | Â | |||
PS 18:0/25:0 | Â | Â | |||
4 | Urine exosome | Phosphatidylserine (PS) | PS 18:1/18:1 | Prostate cancer | [86] |
Lactosylceramide | d18:1/16:0 | Â | Â | ||
PS 18:0–18:2 |  |  | |||
5 | Cerebrospinal fluid | Glycerophospholipids (PL) |  | Alzheimer’s disease | [87] |
Sphingolipids (SL) | Â | Â | Â | ||
6 | Tear | Phospholipids (PL) | Â | Dry eye syndrome | [95] |
Sphingolipids (SL) | Â | Â | Â | ||
Cholesteryl sulfate (CS) | Â | Â | Â | ||
Glycophospholipids | Â | Â | Â | ||
7 | Aqueous humor | Diacylglycerophosphocholines (DAG-PC) |  | Primary open angle glaucoma | |
1-ether 2-acylglycerophosphocholines (PC) | Â | Â | Â | ||
Sphingomyelins (SM) | Â | Â | Â | ||
Phosphocholines (PC) | Â | Â | Â |