From: A systematic approach to cancer: evolution beyond selection
Cognition-based evolution | NeoDarwinian selection model |
---|---|
Self-referential cellular cognition | Differential fitness driving clonal selection |
 Information and communication dependent |  |
 Problem-solving to maintain homeostasis |  |
Non-random communication/problem solving | Stochastic mutations |
Natural cellular engineering | Differential fitness/survival |
Stigmergy/niche construction as problem-solving | Niche construction via clonal selection, |
Reverse evolution/hyperadapability | Random mutation/selection |
Privileged cellular participant/observer status | Passive selection driven participation |
Phenotype as self-referential environmental exploration | Phenotype as a result of clonal selection |
Natural selection is a post facto filter | Natural selection shapes neoplastic phenotype |
Genes/CIN as informational tools and a flexible response system | Random genetic mutations drive neoplasia Genes as code |
Integrated proteomics/transcriptomics | Oncogenes |
Primacy of immunology to sustain self-reference | Immunology as a secondary phenomenon |
Deterministic cellular creativity solves problems | Fitness/selection; stochastic variables |
Initiates as self-directed pathobiont | Random replication error |
 Parasitical homeostasis |  |