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Clinical and Translational Medicine
Figure 1 | Clinical and Translational Medicine

Figure 1

From: Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

Figure 1

Transcription factors and unconventional DNA-binding proteins with significantly altered expression in psoriasis lesions ( n  = 237 patients). (A) Transcription factors. We identified 106 TF-encoding psoriasis DEGs and determined which of these recognize PRE motifs significantly enriched (FDR < 0.10) in sequences upstream of PP-increased DEGs (green background), PP-decreased DEGs (magenta), or both increased and decreased DEGs (yellow). For each DEG, laser capture microdissection data (GSE42114) was used to assess whether its expression is localized to a particular skin compartment (dermis, basal epidermis or suprabasal epidermis). (B) Unconventional DNA-binding proteins. We identified 14 DEGs encoding an uDBP that recognized a PRE motif significantly enriched (FDR < 0.10) in genomic sequences upstream of PP-increased DEGs (green background), PP-decreased DEGs (magenta), or both increased and decreased DEGs (yellow). The figure shows enrichment (Z statistic) for each uDBP motif with respect to sequences upstream of PP-increased and PP-decreased DEGs, respectively, as well as relative expression in dermis, suprabasal epidermis and basal epidermis (laser capture microdissection; GSE42114).

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