Table 1 Major tumor types organized by virulence, clinical significance, and epigenetic markers

Pancreas

2.3%

6.7%

Snail, Twist, Zeb1, Zeb2, E-cadherin, β-catenin Brachyury, HDAC1,2,3, miR-34, miR-200,

Liver

2.8%

16.6%

Snail, Twist, Zeb1, Zeb2, TGF-β, EZH2, HDAC1,2,3, miR-101, STAT3, SUZ12,

Lung

4.0%

16.8%

Snail, Zeb1, Zeb2, E-cadherin, vimentin, α-catenin, EZH2, BMI1, Brachyury, Claudin-1, Cytokeratins, G9a, HDAC1,2,3, LSD1, miR-34, miR-101, miR-205, Periostin, Slug, SUZ12, TTF-1, versican, N-cadherin

Bladder

5.5%

77.4%

Twist, Zeb1, Zeb2, N-cadherin, EZH2, Fibronectin, LSD1, miRs-1/133a/218, miR-19a, miRs-30a-3p/133a/199a, miR-34, miR-99a/100, miR-101, miR-125b, miR-129, miR-145/133a, miR-200, miR-205, miR-221, N-

Renal

12.1%

72.4%

TGF-β, BMP-7, Claudin-1, HDAC1,2,3, hepatocyte growth factor, Klf8, miR-23b, miR-29b, miR-34, miRs-141/200, miR-205, miR-438-3p,

Colorectal

12.9%

64.7%

Snail, Twist, vimentin, Zeb1, Zeb2, β-catenin, Brachyury, CD44, E-cadherin, EZH2^, FGFR4, Fibronectin, HDAC1,2,3, LSD1, miR-34, p16^INK4a, SIRT1, Slug, SUZ12, SUV39H1,

Cervical

16.1%

67.9%

Snail, Twist, E-cadherin, vimentin, β-catenin, EGFR,

Skin melanoma

16.1%

91.3%

TGF-β, MITF, N-cadherin, miR-205

Ovarian

27.4%

44.6%

Snail, Twist, Zeb1, Zeb2, E-cadherin, CCR7, Claudin-1, Fibronectin, Klf8, miR-9, miR-34, miR-200, N-cadherin, Occludin, PTEN, Slug, STK11,

Breast

25.0%

89.2%

Snail, Zeb1, Zeb2, vimentin, β-catenin, E-cadherin, BMI1, Brachyury, Claudin, EZH2, HDAC1,2,3, Klf8, LSD1, miR-9 (2); miR-10b, miR-34, Slug, SUZ12, Twist, versican,

Prostate

28.0%

98.9%

Twist, Zeb1, N-cadherin, APC, Cyclin D2, collagen, decorin, E47, E-cadherin, ER, EZH2, Fibronectin, GSTP1, HDAC1,2,3, Let-7a, LSD1, miR-1, miR-7, miR-15a-16 cluster, miR20a, miR-21, miR-24, miR-32, miR-34a, miR-34c, miR-101, miR-106b, miR-107, miR125b, miR-143, miR-145, miR-146a, miR-148a, miR-205, miR-221, miR-222, miR-331-3P, miR-449a, miR-521, miR-1296, Notch-1, RAR-β2, RASSF1A, versican,

Brain/nervous system

35.6%

33.4%

miR-9, Klf8