Table 4 Selected hematology and biochemistry analysis of male C57BL/6 J mice following single or repeated injections of MSC-NTF cells or the vehicle control
Treatment | ||||
|---|---|---|---|---|
4-week study | 8-week study | 12-week study | ||
Parameter | MSC-NTF cells single injection | MSC-NTF cells 2 injections | MSC-NTF cells 3 injections | Vehicle 3 injections |
No of animals analyzed | 5 | 5 | 5 | 4 |
White blood cells (×103/μL) | 10.4 (1.9) | 11.6 (4.0) | 12.2* (1.8) | 9.9 (0.4) |
Red blood cells (×106/μL) | 9.82 (0.34) | 9.24 (2.6) | 9.72 (1.75) | 9.27 (0.31) |
Hemoglobin (g/dL) | 14.8 (0.1) | 16.3 (2.0) | 15.0 (2.9) | 14.5 (0.4) |
HCT (%) | 50.7 (1.2) | 47.1 (14.0) | 48.1 (9.2) | 47.9 (1.4) |
MCV (U3) | 51.6 (1.2) | 50.8 (1.2) | 49.5** (1.1) | 51.7 (0.5) |
Creatinine (mg/dL) | 0.22 (0.02) | 0.16 (0.04) | 0.17 (0.03) | 0.22 (0.05) |
Urea (mg/dL) | 51.6 (5.3) | 46.0 (8.0) | 53.0 (11.1) | 47.4 (4.1) |
Total Protein (g/dL) | 5.81 (0.17) | 5.75 (0.16) | 5.72 (0.2) | 5.79 (0.17) |
AST (IU/L) | 286 (250) | 192 (80) | 180 (62) | 157 (104) |
ALT (IU/L) | 502 (430) | 163 (69) | 197 (92) | 87 (47) |
ALP (IU/L) | 124 (14) | 89 (7) | 87 (3) | 95 (25) |
Bilirubin (mg/dL) | 0.07 (0.02) | 0.08 (0.01) | 0.08 (0.05) | 0.07 (0.01) |
Cholesterol (mg/dL) | 138 (3) | 144 (12) | 133 (26) | 153 (13) |
TRIG (mg/dL) | 137 (6) | 65 (14) | 70 (27) | 68 (6) |
Phosphorus (mg/dL) | 10.6 (0.8) | 11.4 (0.7) | 10.7 (1.6) | 11.2 (0.8) |
LDH (IU/L) | 1874 (1300) | 906 (197) | 1000 (464) | 735 (331) |