%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2017-12-23T10:23:42+05:30
Springer
2017-12-28T15:37:07+01:00
2017-12-28T15:37:07+01:00
Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
Single-cell sequencing,Cancer,Mutation,Gene expression,Methylation,Heterogeneity,Multi-omics
application/pdf
https://doi.org/10.1186/s40169-017-0177-y
Springer Berlin Heidelberg
Clinical and Translational Medicine, https://doi.org/10.1186/s40169-017-0177-y
Single-cell sequencing
Cancer
Mutation
Gene expression
Methylation
Heterogeneity
Multi-omics
Using single-cell multiple omics approaches to resolve tumor heterogeneity
Michael A. Ortega
Olivier Poirion
Xun Zhu
Sijia Huang
Thomas K. Wolfgruber
Robert Sebra
Lana X. Garmire
10.1186/s40169-017-0177-y
2010-04-23
true
springer.com
springerlink.com
https://doi.org/10.1186/s40169-017-0177-y
10.1186/s40169-017-0177-y
2001-1326
journal
Clinical and Translational Medicine
The Author(s)
2010-04-23
true
10.1186/s40169-017-0177-y
noindex
springer.com
springerlink.com
VoR
uuid:0e92d808-aa1e-48a9-8b88-10bd97a8981e
uuid:68aa0577-0317-4497-92d4-9b90941fe93f
default
1
converted
uuid:42478af5-594c-4171-bf42-48e30103ffa1
converted to PDF/A-2b
pdfToolbox
2017-12-23T10:24:35+05:30
2
B
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
3 0 obj
<>
endobj
8 0 obj
[9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R]
endobj
9 0 obj
<>/Rect[130.701 392.109 135.621 379.942]/H/N/AP<>>>
endobj
10 0 obj
<>/Rect[530.517 356.109 535.388 343.942]/H/N/AP<>>>
endobj
11 0 obj
<>/Rect[307.87 344.109 317.611 331.942]/H/N/AP<>>>
endobj
12 0 obj
<>/Rect[322.745 344.109 332.486 331.942]/H/N/AP<>>>
endobj
13 0 obj
<>/Rect[522.913 320.109 532.654 307.942]/H/N/AP<>>>
endobj
14 0 obj
<>/Rect[304.724 308.109 314.466 295.942]/H/N/AP<>>>
endobj
15 0 obj
<>/Rect[509.395 224.109 514.266 211.942]/H/N/AP<>>>
endobj
16 0 obj
<>/Rect[523.461 224.109 533.203 211.942]/H/N/AP<>>>
endobj
17 0 obj
<>/Rect[418.409 188.109 428.15 175.942]/H/N/AP<>>>
endobj
18 0 obj
<>/Rect[434.483 188.109 444.224 175.942]/H/N/AP<>>>
endobj
19 0 obj
<>/Rect[371.873 140.109 381.614 127.942]/H/N/AP<>>>
endobj
20 0 obj
<>/Rect[387.494 140.109 397.235 127.942]/H/N/AP<>>>
endobj
21 0 obj
<>/Rect[155.66 290.306 163.468 281.242]/H/N/AP<>>>
endobj
22 0 obj
<>/Rect[152.204 278.206 160.012 269.142]/H/N/AP<>>>
endobj
23 0 obj
<>/Rect[159.276 266.106 167.084 257.042]/H/N/AP<>>>
endobj
24 0 obj
<>/Rect[149.436 254.006 157.244 244.942]/H/N/AP<>>>
endobj
25 0 obj
<>/Rect[178.036 241.906 185.844 232.842]/H/N/AP<>>>
endobj
26 0 obj
<>/Rect[161.788 229.806 169.595 220.742]/H/N/AP<>>>
endobj
27 0 obj
<>/Rect[155.804 217.706 163.612 208.642]/H/N/AP<>>>
endobj
28 0 obj
<>/Rect[153.492 205.606 161.3 196.542]/H/N/AP<>>>
endobj
29 0 obj
<>/Rect[145.756 193.506 153.564 184.442]/H/N/AP<>>>
endobj
30 0 obj
<>/Rect[127.925 172.406 135.732 163.342]/H/N/AP<>>>
endobj
31 0 obj
<>/Rect[174.939 160.306 182.747 151.242]/H/N/AP<>>>
endobj
32 0 obj
<>/Rect[153.596 148.206 161.404 139.142]/H/N/AP<>>>
endobj
33 0 obj
<>/Rect[150.956 136.056 158.764 126.992]/H/N/AP<>>>
endobj
6 0 obj
<>/XObject<>/ProcSet[/PDF/Text/ImageC]/Font<>>>
endobj
5 0 obj
<>stream
xZ[oFv?!b!dTX`<:x7V`&fMlʿy_LSEI:ٌǣV.TQ|ZHA[^B"gSa(VH"IIfXm߹~wE{+T~2<,|OX۽CwcM4h^䵫㉷uՈ)gćK|rEarRoox.viG_ Eig{qgS)ddiH*qլe)L4?J]*%?QSRuSN4n74ȚTͣțⷶ)yZ+VOQ;2/k'I`)PAm~UT8UE,XsSat?Ƃғ2ig/U9y-v$c
7w"(vG5-S)s"fGѴPGX^?z]ffCE:Ur8u-v{x0 tڽ`>Jc\;}$&aE