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  1. Research

    Styrene maleic acid encapsulated raloxifene micelles for management of inflammatory bowel disease

    Inflammatory bowel disease (IBD) comprises a group of disorders that manifest through chronic inflammation of the colon and small intestine. Although the exact cause of IBD is still unclear, dysfunctional immu...

    Khaled Greish, Safa Taha, Anfal Jasim, Sara Abd Elghany, Ameera Sultan, Ali AlKhateeb, Manal Othman, Fang Jun, Sebastien Taurin and Moiz Bakhiet

    Clinical and Translational Medicine 2017 6:28

    Published on: 3 August 2017

  2. Review

    Lipidomics and anti-trypanosomatid chemotherapy

    Trypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactor...

    Michael Biagiotti, Sedelia Dominguez, Nader Yamout and Rachel Zufferey

    Clinical and Translational Medicine 2017 6:27

    Published on: 1 August 2017

  3. Research

    CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study

    CXCL9-11 polymorphisms are related to various infectious diseases, including hepatitis C virus (HCV) infection. In this study, we analyzed the association between CXCL9-11 polymorphism...

    María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalban, Sonia Vázquez-Morón, Pablo Ryan and Salvador Resino

    Clinical and Translational Medicine 2017 6:26

    Published on: 28 July 2017

  4. Review

    Significance of long chain polyunsaturated fatty acids in human health

    In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid me...

    Rafael Zárate, Nabil el Jaber-Vazdekis, Noemi Tejera, José A. Pérez and Covadonga Rodríguez

    Clinical and Translational Medicine 2017 6:25

    Published on: 27 July 2017

  5. Review

    Autophagy and inflammation

    Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have...

    Mengjia Qian, Xiaocong Fang and Xiangdong Wang

    Clinical and Translational Medicine 2017 6:24

    Published on: 26 July 2017

  6. Review

    Biofluid lipidome: a source for potential diagnostic biomarkers

    Lipidomics is the identification and quantitation of changes in the lipidome of a cell, tissue, organ or biofluid in health and disease using high resolution mass spectrometry. Lipidome of a particular organis...

    Arkasubhra Ghosh and Krishnatej Nishtala

    Clinical and Translational Medicine 2017 6:22

    Published on: 20 June 2017

  7. Review

    Single-cell RNA-sequencing of the brain

    Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network...

    Raquel Cuevas-Diaz Duran, Haichao Wei and Jia Qian Wu

    Clinical and Translational Medicine 2017 6:20

    Published on: 8 June 2017

  8. Review

    Can glypican-3 be a disease-specific biomarker?

    Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress...

    Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen

    Clinical and Translational Medicine 2017 6:18

    Published on: 16 May 2017

  9. Review

    ETS-targeted therapy: can it substitute for MEK inhibitors?

    The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm...

    Osamu Tetsu and Frank McCormick

    Clinical and Translational Medicine 2017 6:16

    Published on: 2 May 2017

  10. Review

    Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis

    Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

    Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

    Clinical and Translational Medicine 2017 6:15

    Published on: 12 April 2017

  11. Perspective

    Translational research in pediatric pulmonary disease, 2017

    As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

    Bruce K. Rubin

    Clinical and Translational Medicine 2017 6:12

    Published on: 1 March 2017

  12. Review

    Single cell sequencing: a distinct new field

    Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

    Jian Wang and Yuanlin Song

    Clinical and Translational Medicine 2017 6:10

    Published on: 20 February 2017

  13. Commentary

    Integrating phosphoproteomics into the clinical management of prostate cancer

    Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

    Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

    Clinical and Translational Medicine 2017 6:9

    Published on: 14 February 2017

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