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  1. Content type: Case report

    Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, clas...

    Authors: Patrice E. Poubelle, Nathalie Pagé, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier and Martin Pelletier

    Citation: Clinical and Translational Medicine 2019 8:19

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  2. Content type: Research

    Glioblastoma is the most common and malignant brain tumor in adults. Glioblastoma is usually fatal 12–15 months after diagnosis and the current possibilities in therapy are mostly only palliative. Therefore, n...

    Authors: Svenja Busch, Marina Talamini, Steffen Brenner, Amr Abdulazim, Daniel Hänggi, Michael Neumaier, Marcel Seiz-Rosenhagen and Tina Fuchs

    Citation: Clinical and Translational Medicine 2019 8:18

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  3. Content type: Review

    Considering the important role of microbiome, many of current investigations have focused on its beneficial aspects. Although, research explores new dimensions of the impact of microbiome and examines the diff...

    Authors: Ava Behrouzi, Amir Hossein Nafari and Seyed Davar Siadat

    Citation: Clinical and Translational Medicine 2019 8:16

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  4. Content type: Review

    In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the...

    Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Citation: Clinical and Translational Medicine 2019 8:13

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  5. Content type: Research

    A positive family history for diabetes, cardiovascular diseases or various types of cancer increases the relative risk for these diseases by 2 to 5 times compared to people without a positive family history. T...

    Authors: Elisa J. F. Houwink, Olga R. Hortensius, Kees van Boven, Annet Sollie and Mattijs E. Numans

    Citation: Clinical and Translational Medicine 2019 8:17

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  6. Content type: Research

    Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients’ follow-up, several studies have eva...

    Authors: Hanifeh Mirtavoos-Mahyari, Soudeh Ghafouri-Fard, Adnan Khosravi, Elahe Motevaseli, Zahra Esfahani-Monfared, Sharareh Seifi, Babak Salimi, Vahid Kholghi Oskooei, Mohsen Ghadami and Mohammad Hossein Modarressi

    Citation: Clinical and Translational Medicine 2019 8:14

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  7. Content type: Review

    Chronic obstructive pulmonary disease (COPD) is expected to climb on the podium of the leading causes of mortality worldwide in the upcoming decade. Clinical diagnosis of COPD has classically relied upon detec...

    Authors: Lukasz A. Myc, Yun M. Shim, Victor E. Laubach and Julien Dimastromatteo

    Citation: Clinical and Translational Medicine 2019 8:12

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  8. Content type: Research

    Multiple sclerosis (MS) is a chronic disease characterized by demyelination, glial activation and axonal degeneration in the central nervous system. At the present, there is no certain remedy for this disease....

    Authors: Mehrdokht Mazdeh, Shahriar Kargar Monhaser, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:11

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  9. Content type: Review

    Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune ce...

    Authors: S. K. Daniel, K. M. Sullivan, K. P. Labadie and V. G. Pillarisetty

    Citation: Clinical and Translational Medicine 2019 8:10

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  10. Content type: Review

    There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protei...

    Authors: Jun Gong, Alexander Chehrazi-Raffle, Veronica Placencio-Hickok, Michelle Guan, Andrew Hendifar and Ravi Salgia

    Citation: Clinical and Translational Medicine 2019 8:9

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  11. Content type: Review

    Nanoparticles have seen considerable popularity as effective tools for drug delivery. However, non-specific targeting continues to remain a challenge. Recently, biomimetic nanoparticles have emerged as an inno...

    Authors: Anna Pasto, Federica Giordano, Michael Evangelopoulos, Alberto Amadori and Ennio Tasciotti

    Citation: Clinical and Translational Medicine 2019 8:8

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  12. Content type: Research

    Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are re...

    Authors: Deviyani M. Rao, Della T. Phan, Michelle J. Choo, Michael R. Weaver, Rebecca E. Oberley-Deegan, Russell P. Bowler and Fabienne Gally

    Citation: Clinical and Translational Medicine 2019 8:7

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  13. Content type: Research

    Patients with transient ischemic attack (TIA) or minor stroke are at risk of strokes. One of the precautionary measures to reduce risk of stroke in these patients is administration of antiplatelet drugs.

    Authors: Mojtaba Khazaei, Fateme Ghasemian, Mehrdokht Mazdeh, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:6

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  14. Content type: Correction

    The Editor of this journal has published this Expression of Concern to alert readers that, following publication of the article [1], it came to light that there were undeclared competing interests that have a ...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2019 8:5

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    The original article was published in Clinical and Translational Medicine 2016 5:40

  15. Content type: Research

    This study aims to clarify the prognostic role of epidermal growth factor receptor (EGFR) mutations in plasma of non-small cell lung cancer (NSCLC) for resistance to tyrosine kinase inhibitor (TKI), in correlatio...

    Authors: Thang Thanh Phan, Bich-Thu Tran, Son Truong Nguyen, Toan Trong Ho, Hang Thuy Nguyen, Vu Thuong Le and Anh Tuan Le

    Citation: Clinical and Translational Medicine 2019 8:4

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  16. Content type: Research

    Long chain omega-3 fatty acids (omega-3 FAs) supplements have been shown to exert beneficial effects in patients with epilepsy through elevation of seizure thresholds and dampening of inflammatory responses. I...

    Authors: Shaghayegh Omrani, Mohammad Taheri, Mir Davood Omrani, Shahram Arsang-Jang and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:3

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  17. Content type: Review

    Pancreatic cancer is one of the leading causes of cancer-related death in the United States and survival outcomes remain dismal despite significant advances in molecular diagnostics and therapeutics in clinica...

    Authors: Burak Uzunparmak and Ibrahim Halil Sahin

    Citation: Clinical and Translational Medicine 2019 8:2

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  18. Content type: Research

    Sjögren’s syndrome (SS) is an autoimmune disease characterized by immune attack on the salivary and lacrimal glands. Given the known cytokine activation and type I interferon gene expression signature found in...

    Authors: Peter D. Burbelo, Sarah Browne, Steve M. Holland, Michael J. Iadarola and Ilias Alevizos

    Citation: Clinical and Translational Medicine 2019 8:1

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  19. Content type: Review

    Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle‐income countries. Children, w...

    Authors: Rajendra KC, Shakti D. Shukla, Sanjay S. Gautam, Philip M. Hansbro and Ronan F. O’Toole

    Citation: Clinical and Translational Medicine 2018 7:39

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  20. Content type: Research

    Multiple sclerosis (MS) is a progressive immune-related disorder of the central nervous system leading to destruction of myelin sheaths. Natalizumab is a humanized monoclonal antibody against the cell adhesion...

    Authors: Mehrdokht Mazdeh, Shno Hosseini, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2018 7:38

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  21. Content type: Review

    Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results in breakdown of cartilage in joints and causes the patient to experience intense pain and even disability. The pa...

    Authors: Santul Bapat, Daniel Hubbard, Akul Munjal, Monte Hunter and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2018 7:36

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  22. Content type: Research

    Adherence is critical for successful topical, vaginally delivered anti-retroviral (ARV)-based HIV pre-exposure prophylaxis (PrEP). Quantitating systemic or tissue ARV levels through LC–MS/MS is currently viewe...

    Authors: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Susan Ju, Jill L. Schwartz, Andrea R. Thurman and Gustavo F. Doncel

    Citation: Clinical and Translational Medicine 2018 7:37

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  23. Content type: Review

    Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent...

    Authors: Yong Zhang

    Citation: Clinical and Translational Medicine 2018 7:34

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  24. Content type: Review

    Immune checkpoint inhibitors have demonstrated broad single-agent antitumor activity and a favorable safety profile that render them attractive agents to combine with other systemic anticancer therapies. Pancr...

    Authors: Jun Gong, Andrew Hendifar, Richard Tuli, Jeremy Chuang, May Cho, Vincent Chung, Daneng Li and Ravi Salgia

    Citation: Clinical and Translational Medicine 2018 7:32

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  25. Content type: Review

    Human tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensi...

    Authors: Naasson Tuyiringire, Deusdedit Tusubira, Jean-Pierre Munyampundu, Casim Umba Tolo, Claude M. Muvunyi and Patrick Engeu Ogwang

    Citation: Clinical and Translational Medicine 2018 7:29

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  26. Content type: Case report

    Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstra...

    Authors: Hans Raskov, Kasper Nørskov Kragh, Thomas Bjarnsholt, Mahdi Alamili and Ismail Gögenur

    Citation: Clinical and Translational Medicine 2018 7:30

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  27. Content type: Retraction Note

    The Editor-in-Chief is retracting this article because the authors have not obtained consent to publish from the patient whose details are described in this case report. The article has been removed to protect...

    Authors: Christopher D. Phillips, Pornpatcharin Wongsaisri, Thein Htut and Terry Grossman

    Citation: Clinical and Translational Medicine 2018 7:31

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    The original article was published in Clinical and Translational Medicine 2017 6:31

  28. Content type: Research

    In low and middle income countries, human immunodeficiency virus (HIV) exposed, uninfected (HEU) infants demonstrate higher morbidity and mortality than their unexposed counterparts. To determine possible immu...

    Authors: Barbara Lohman-Payne, Benjamin Gabriel, Sangshin Park, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Carey Farquhar, Rose Kerubo Bosire and Grace John-Stewart

    Citation: Clinical and Translational Medicine 2018 7:26

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  29. Content type: Review

    Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce a...

    Authors: Weilong Chen, Yuanyuan Qin and Suling Liu

    Citation: Clinical and Translational Medicine 2018 7:27

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  30. Content type: Research

    HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP...

    Authors: Monique R. Anderson, Michelle L. Pleet, Yoshimi Enose-Akahata, James Erickson, Maria Chiara Monaco, Yao Akpamagbo, Ashley Velluci, Yuetsu Tanaka, Shila Azodi, Ben Lepene, Jennifer Jones, Fatah Kashanchi and Steven Jacobson

    Citation: Clinical and Translational Medicine 2018 7:24

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  31. Content type: Research

    We present the Cancer Moonshot clinical project located at the European center in Lund. Here, tissue and blood samples have been collected and stored in a large-scale biobank. Multiple clinical centers around ...

    Authors: Johan Malm, Yutaka Sugihara, Marcell Szasz, Ho Jeong Kwon, Henrik Lindberg, Roger Appelqvist and György Marko-Varga

    Citation: Clinical and Translational Medicine 2018 7:28

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  32. Content type: Review

    Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. O...

    Authors: Oleg Dobrokhotov, Mikhail Samsonov, Masahiro Sokabe and Hiroaki Hirata

    Citation: Clinical and Translational Medicine 2018 7:23

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  33. Content type: Research

    Currently, only a limited number of molecular biomarkers for malignant melanoma exist. This is the case for both diagnosing the disease, staging, and efficiently measuring the response to therapy by tracing th...

    Authors: Yutaka Sugihara, Daniel Rivas, Johan Malm, Marcell Szasz, HoJeong Kwon, Bo Baldetorp, Håkan Olsson, Christian Ingvar, Melinda Rezeli, Thomas E. Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2018 7:22

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  34. Content type: Commentary

    The prevention, diagnosis and targeted therapies of cancer are important in cancer controlling and treatment. The present challenge about cancer biomarker still remains in identifying the special biomarkers fo...

    Authors: Furong Yan, Hong Zhao and Yiming Zeng

    Citation: Clinical and Translational Medicine 2018 7:21

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  35. Content type: Review

    Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeut...

    Authors: Paige M. Glumac and Aaron M. LeBeau

    Citation: Clinical and Translational Medicine 2018 7:18

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  36. Content type: Perspective

    Maintenance of health involves a synchronized network of catabolic and anabolic signals among organs/tissues/cells that requires differential bioenergetics from mitochondria and glycolysis (biological laws or ...

    Authors: Mahin Khatami

    Citation: Clinical and Translational Medicine 2018 7:20

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  37. Content type: Research

    Pulmonary endothelial cells’ (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction o...

    Authors: Trushil Shah, Shanshan Qin, Mona Vashi, Dan N. Predescu, Niranjan Jeganathan, Cristina Bardita, Balaji Ganesh, Salvatore diBartolo, Louis F. Fogg, Robert A. Balk and Sanda A. Predescu

    Citation: Clinical and Translational Medicine 2018 7:19

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  38. Content type: Research

    Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a ti...

    Authors: Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams III, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh and Steven Idell

    Citation: Clinical and Translational Medicine 2018 7:17

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  39. Content type: Review

    Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like meta...

    Authors: Lillian Truong, Yun-Min Zheng, Tengyao Song, Yi Tang and Yong-Xiao Wang

    Citation: Clinical and Translational Medicine 2018 7:16

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  40. Content type: Research

    Because of its advantage as a minimally invasive procedure, nasal brushings have been increasingly used and proposed as a valuable approach to study lower airway diseases in lieu of bronchial epithelial cells....

    Authors: Nicole Roberts, Reem Al Mubarak, David Francisco, Monica Kraft and Hong Wei Chu

    Citation: Clinical and Translational Medicine 2018 7:13

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  41. Content type: Commentary

    Lipidomics is a measurement of a large scale of lipid species to understand roles of their carbon atoms, dual bonds, or isomerism in the lipid molecule. Clinical lipidomics was recently defined “as a new integ...

    Authors: Jiapei Lv, Linlin Zhang, Furong Yan and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2018 7:12

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  42. Content type: Commentary

    Optimal Independent Review Board (IRB) structure encompasses ongoing process improvement, ethics policies and continuous relationship building, all sound in evidence. With optimal IRB structure, a global resea...

    Authors: Julie Babyar

    Citation: Clinical and Translational Medicine 2018 7:10

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  43. Content type: Research

    Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A—induced proinflammator...

    Authors: Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto

    Citation: Clinical and Translational Medicine 2018 7:9

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  44. Content type: Correction

    In this Correction, the authors would like to acknowledge that the original publication of the article “A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in th...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2018 7:8

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    The original article was published in Clinical and Translational Medicine 2016 5:3

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