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  1. Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivit...

    Authors: Jing Bi, Zhihui Min, Honglei Yuan, Zhilong Jiang, Ruolin Mao, Tao Zhu, Chunfang Liu, Yuzhen Zeng, Juan Song, Chunling Du and Zhihong Chen

    Citation: Clinical and Translational Medicine 2020 9:22

    Content type: Research

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  2. To explore the genetic correlation between schizophrenia (SCZ) and osteoporosis (OP).

    Authors: Li Liu, Yan Wen, Yujie Ning, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Tielin Yang, Xiangding Chen, Lijun Tan, Hui Shen, Qing Tian, Hong-Wen Deng…

    Citation: Clinical and Translational Medicine 2020 9:21

    Content type: Research

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  3. An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, person-to-person transmission in family ...

    Authors: Jun She, Jinjun Jiang, Ling Ye, Lijuan Hu, Chunxue Bai and Yuanlin Song

    Citation: Clinical and Translational Medicine 2020 9:19

    Content type: Review

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  4. Newer epidemiological studies suggest that the incidence of ulcerative colitis might be increasing rapidly. Furthermore, osteoporosis in ulcerative colitis patients has gained great attention, but the epidemio...

    Authors: Tianyu Zhou, Jiaqi Pan, Bin Lai, Li Cen, Wenxi Jiang, Chaohui Yu and Zhe Shen

    Citation: Clinical and Translational Medicine 2020 9:18

    Content type: Review

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  5. Despite the impressive anti-tumor activity of osimertinib in epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC) patients, 30–40% of patients still show limited response. ...

    Authors: Qiufan Zheng, Shaodong Hong, Yan Huang, Hongyun Zhao, Yunpeng Yang, Xue Hou, Yuanyuan Zhao, Yuxiang Ma, Ting Zhou, Yaxiong Zhang, Wenfeng Fang and Li Zhang

    Citation: Clinical and Translational Medicine 2020 9:17

    Content type: Research

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  6. The Peroxisome proliferator-activated receptor gamma gene (PPARG), encodes a member of the peroxisome-activated receptor subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) wh...

    Authors: Howeida Abdullah Mustafa, Afraa Mohamed Suliman Albkrye, Buthiena Mohamed AbdAlla, Mona AbdelRahman Mohammed Khair, Nidal Abdelwahid and Hind Abdelaziz Elnasri

    Citation: Clinical and Translational Medicine 2020 9:7

    Content type: Research

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  7. The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim w...

    Authors: Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang and Naibo Yang

    Citation: Clinical and Translational Medicine 2020 9:16

    Content type: Research

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  8. Accumulating evidence demonstrated immune/inflammation-related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of se...

    Authors: Qi Liu, Dakui Luo, Sanjun Cai, Qingguo Li and Xinxiang Li

    Citation: Clinical and Translational Medicine 2020 9:6

    Content type: Research

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  9. At our facilities, patients that received embryos using donor oocyte during in vitro fertilization (IVF), usually have had at least one failed attempt to produce at least one euploid embryo with their own oocy...

    Authors: Elizabeth Schaeffer, Leonardo M. Porchia, Adina Neumann, Almena Luna, Tania Rojas and Esther López-Bayghen

    Citation: Clinical and Translational Medicine 2020 9:14

    Content type: Research

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  10. Liver fibrosis, resulted from several liver diseases, are increasing up to 25% in population in global. It remains undetermined how much impact liver fibrosis have on the development of hepatic metastasis and ...

    Authors: Xiang Hu, Audrey Marietta, Wei-Xing Dai, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai and Jun-Jie Peng

    Citation: Clinical and Translational Medicine 2020 9:13

    Content type: Research

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  11. Completion of the human genome sequencing project highlighted the richness of the cellular RNA world, and opened the door to the discovery of a plethora of short and long non-coding RNAs (the dark transcriptom...

    Authors: Estanislao Navarro, Adrian Mallén, Josep M. Cruzado, Joan Torras and Miguel Hueso

    Citation: Clinical and Translational Medicine 2020 9:5

    Content type: Review

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  12. To develop and validate radiomic prediction models using contrast-enhanced computed tomography (CE-CT) to preoperatively predict Ki-67 expression in gastrointestinal stromal tumors (GISTs).

    Authors: Qing-Wei Zhang, Yun-Jie Gao, Ran-Ying Zhang, Xiao-Xuan Zhou, Shuang-Li Chen, Yan Zhang, Qiang Liu, Jian-Rong Xu and Zhi-Zheng Ge

    Citation: Clinical and Translational Medicine 2020 9:12

    Content type: Research

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  13. Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms ac...

    Authors: Tom N. Durrant and Ingeborg Hers

    Citation: Clinical and Translational Medicine 2020 9:8

    Content type: Review

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  14. Instructions for administering some drugs and indications for their use raise certain dilemmas and controversies questioning the appropriateness of the treatment in this way. In this article, some controversie...

    Authors: Enver Zerem

    Citation: Clinical and Translational Medicine 2020 9:11

    Content type: Perspective

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  15. The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone a...

    Authors: Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang and Liang Zeng

    Citation: Clinical and Translational Medicine 2020 9:10

    Content type: Research

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  16. Fetal growth restriction (FGR) contributes the primary cause of perinatal mortality and morbidity with impacts on the long-term health. To determine the core gene expression network and gene signatures, which ...

    Authors: Guiying Wang, Jun Yu, Yiwei Yang, Xiaoqin Liu, Xiaobo Zhao, Xudong Guo, Tao Duan, Chenqi Lu and Jiuhong Kang

    Citation: Clinical and Translational Medicine 2020 9:9

    Content type: Research

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  17. The present study sought to identify a panel of DNA markers for noninvasive diagnosis using cell-free DNA (cfDNA) from urine supernatant or cellular DNA from urine sediments of hematuria patients. A panel of 4...

    Authors: Zhenyu Ou, Kai Li, Ting Yang, Ying Dai, Mohan Chandra, Jun Ning, Yongli Wang, Ran Xu, Tangjie Gao, Yu Xie, Qing He, Yuanwei Li, Qin Lu, Long Wang and Zhuo Song

    Citation: Clinical and Translational Medicine 2020 9:4

    Content type: Research

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  18. The incidence and mortality rates of gastric cancer (GC) rank in top five among all malignant tumors. Chemokines and their receptor-signaling pathways reportedly play key roles in the metastasis of malignant t...

    Authors: Xing Wan, Yongxi Song, Honghong Fang, Ling Xu, Xiaofang Che, Shuo Wang, Xiaomeng Zhang, Lingyun Zhang, Ce Li, Yibo Fan, Kezuo Hou, Zhi Li, Xueqing Wang, Yunpeng Liu and Xiujuan Qu

    Citation: Clinical and Translational Medicine 2020 9:3

    Content type: Research

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  19. Serum amyloid A (SAA) has been associated with the development and prognosis of cancer. The purpose of this study was to evaluate the predictive value of integration of pretreatment SAA–EBV DNA (S-D) grade and...

    Authors: Jianpei Li, Changchun Lai, Songguo Peng, Hao Chen, Lei Zhou, Yufeng Chen and Shulin Chen

    Citation: Clinical and Translational Medicine 2020 9:2

    Content type: Research

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  20. Despite the well described heterogeneity in glioblastoma (GBM), treatment is standardized, and clinical trials investigate treatment effects at population level. Genomics-driven oncology for stratified treatme...

    Authors: Erlend Skaga, Evgeny Kulesskiy, Marit Brynjulvsen, Cecilie J. Sandberg, Swapnil Potdar, Iver A. Langmoen, Aki Laakso, Emília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo

    Citation: Clinical and Translational Medicine 2019 8:33

    Content type: Research

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  21. Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysreg...

    Authors: Dickson Kofi Wiredu Ocansey, Li Wang, Jingyan Wang, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu and Fei Mao

    Citation: Clinical and Translational Medicine 2019 8:31

    Content type: Review

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  22. Bone is a preferential site for prostate cancer (PCa) metastasis. However, sites of synchronous distant metastases in PCa patients with bone metastases at initial diagnosis and their impacts on prognosis are s...

    Authors: Feng Zhao, Jili Wang, Meiqin Chen, Danni Chen, Sunyi Ye, Xinke Li, Xin Chen, Guoping Ren and Senxiang Yan

    Citation: Clinical and Translational Medicine 2019 8:30

    Content type: Research

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  23. Aberrant expression or hyperactivation of aromatase (CYP19A1)–estrogen receptor (ESR) axis is well identified as one of the major causes of breast cancer. Lots of drugs have been developed for targeting CYP19A...

    Authors: Xing Huang

    Citation: Clinical and Translational Medicine 2019 8:29

    Content type: Commentary

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  24. High-grade serous ovarian cancer (HGSC), the most common ovarian carcinoma type, is associated with the highest mortality rate among all gynecological malignancies. As chemoresistance has been demonstrated as ...

    Authors: Xin Qi, Chunjiang Yu, Yi Wang, Yuxin Lin and Bairong Shen

    Citation: Clinical and Translational Medicine 2019 8:28

    Content type: Research

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  25. The last decade has seen a dramatic increase in the availability of scientific data, where human-related biological databases have grown not only in count but also in volume, posing unprecedented challenges in...

    Authors: Zeeshan Ahmed, Saman Zeeshan, Ruoyun Xiong and Bruce T. Liang

    Citation: Clinical and Translational Medicine 2019 8:26

    Content type: Short report

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  26. Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung condition associated with significant morbidity and mortality. Unfortunately, the current treatment for this disease is mainly...

    Authors: Trushil G. Shah, Dan Predescu and Sanda Predescu

    Citation: Clinical and Translational Medicine 2019 8:25

    Content type: Review

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  27. Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss co...

    Authors: Evgeny Chirshev, Kerby C. Oberg, Yevgeniya J. Ioffe and Juli J. Unternaehrer

    Citation: Clinical and Translational Medicine 2019 8:24

    Content type: Review

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  28. In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular altera...

    Authors: Mariangela Torniai, Laura Scortichini, Francesca Tronconi, Corrado Rubini, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti and Rossana Berardi

    Citation: Clinical and Translational Medicine 2019 8:22

    Content type: Review

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  29. Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delega...

    Authors: Tovah Williamson, Nikhila Sultanpuram and Hossein Sendi

    Citation: Clinical and Translational Medicine 2019 8:21

    Content type: Review

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  30. Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. Fatigue may interfere with daily work and activities. Different pharmacological and non-pharmacolog...

    Authors: Mojtaba Khazaei, Ashkan Karevan, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:20

    Content type: Research

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  31. Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, clas...

    Authors: Patrice E. Poubelle, Nathalie Pagé, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier and Martin Pelletier

    Citation: Clinical and Translational Medicine 2019 8:19

    Content type: Case report

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  32. Glioblastoma is the most common and malignant brain tumor in adults. Glioblastoma is usually fatal 12–15 months after diagnosis and the current possibilities in therapy are mostly only palliative. Therefore, n...

    Authors: Svenja Busch, Marina Talamini, Steffen Brenner, Amr Abdulazim, Daniel Hänggi, Michael Neumaier, Marcel Seiz-Rosenhagen and Tina Fuchs

    Citation: Clinical and Translational Medicine 2019 8:18

    Content type: Research

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  33. Considering the important role of microbiome, many of current investigations have focused on its beneficial aspects. Although, research explores new dimensions of the impact of microbiome and examines the diff...

    Authors: Ava Behrouzi, Amir Hossein Nafari and Seyed Davar Siadat

    Citation: Clinical and Translational Medicine 2019 8:16

    Content type: Review

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  34. In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the...

    Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Citation: Clinical and Translational Medicine 2019 8:13

    Content type: Review

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  35. A positive family history for diabetes, cardiovascular diseases or various types of cancer increases the relative risk for these diseases by 2 to 5 times compared to people without a positive family history. T...

    Authors: Elisa J. F. Houwink, Olga R. Hortensius, Kees van Boven, Annet Sollie and Mattijs E. Numans

    Citation: Clinical and Translational Medicine 2019 8:17

    Content type: Research

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  36. Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients’ follow-up, several studies have eva...

    Authors: Hanifeh Mirtavoos-Mahyari, Soudeh Ghafouri-Fard, Adnan Khosravi, Elahe Motevaseli, Zahra Esfahani-Monfared, Sharareh Seifi, Babak Salimi, Vahid Kholghi Oskooei, Mohsen Ghadami and Mohammad Hossein Modarressi

    Citation: Clinical and Translational Medicine 2019 8:14

    Content type: Research

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  37. Chronic obstructive pulmonary disease (COPD) is expected to climb on the podium of the leading causes of mortality worldwide in the upcoming decade. Clinical diagnosis of COPD has classically relied upon detec...

    Authors: Lukasz A. Myc, Yun M. Shim, Victor E. Laubach and Julien Dimastromatteo

    Citation: Clinical and Translational Medicine 2019 8:12

    Content type: Review

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  38. Multiple sclerosis (MS) is a chronic disease characterized by demyelination, glial activation and axonal degeneration in the central nervous system. At the present, there is no certain remedy for this disease....

    Authors: Mehrdokht Mazdeh, Shahriar Kargar Monhaser, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:11

    Content type: Research

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  39. Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune ce...

    Authors: S. K. Daniel, K. M. Sullivan, K. P. Labadie and V. G. Pillarisetty

    Citation: Clinical and Translational Medicine 2019 8:10

    Content type: Review

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  40. There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protei...

    Authors: Jun Gong, Alexander Chehrazi-Raffle, Veronica Placencio-Hickok, Michelle Guan, Andrew Hendifar and Ravi Salgia

    Citation: Clinical and Translational Medicine 2019 8:9

    Content type: Review

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  41. Nanoparticles have seen considerable popularity as effective tools for drug delivery. However, non-specific targeting continues to remain a challenge. Recently, biomimetic nanoparticles have emerged as an inno...

    Authors: Anna Pasto, Federica Giordano, Michael Evangelopoulos, Alberto Amadori and Ennio Tasciotti

    Citation: Clinical and Translational Medicine 2019 8:8

    Content type: Review

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  42. Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are re...

    Authors: Deviyani M. Rao, Della T. Phan, Michelle J. Choo, Michael R. Weaver, Rebecca E. Oberley-Deegan, Russell P. Bowler and Fabienne Gally

    Citation: Clinical and Translational Medicine 2019 8:7

    Content type: Research

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  43. Patients with transient ischemic attack (TIA) or minor stroke are at risk of strokes. One of the precautionary measures to reduce risk of stroke in these patients is administration of antiplatelet drugs.

    Authors: Mojtaba Khazaei, Fateme Ghasemian, Mehrdokht Mazdeh, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:6

    Content type: Research

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  44. The Editor of this journal has published this Expression of Concern to alert readers that, following publication of the article [1], it came to light that there were undeclared competing interests that have a ...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2019 8:5

    Content type: Correction

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    The original article was published in Clinical and Translational Medicine 2016 5:40