Fig. 4

Correlation between T790M relative mutation purity (RMP) and osimertinib treatment outcomes. a Objective response rate (ORR) stratified by T790M RMP quartiles (P for trend = 0.002). b Progression-free survival (PFS) stratified by T790M RMP quartiles (P for trend = 0.006). c Receiver Operating Characteristic (ROC) Curve and area under ROC curve for T790M RMP predicting objective response. d ORR stratified by RMP-low and RMP-high patients (21.1% vs 65.6%, P = 0.002). e PFS stratified by RMP-low and RMP-high patients (P = 0.013, log-rank test)