Embryos derived from donor or patient oocytes are not different for in vitro fertilization outcomes when PGT allows euploid embryo selection: a retrospective study

Clinical and Translational Medicine

Table 4 Comparison of clinical outcomes in recipients of embryos derived by donor or patient oocytes

Clinical outcomes	N^a	Total		p^b	Age ≤ 37		p^c	Age ≥ 38		p^d
Clinical outcomes	N^a	Patient oocytes (%)	Donor oocytes (%)	p^b	Patient oocytes (%)	Donor oocytes (%)	p^c	Patient oocytes (%)	Donor oocytes (%)	p^d
Implantation^e	1–3	188/402 (46.7)	97/190 (50.8)	0.35	117/227 (51.5)	10/19 (52.6)	0.93	71/175 (40.6)	87/171 (50.9)	0.06
	1	46/163 (28.2)	9/40 (22.5)	0.47	13/52 (25.0)	1/5 (20.0)	0.80	33/111 (29.7)	8/35 (22.9)	0.43
	2	111/192 (57.8)	65/109 (59.6)	0.76	80/143 (55.9)	6/10 (60.0)	0.80	31/49 (63.3)	59/99 (59.6)	0.67
	3	31/47 (66.0)	23/41 (56.1)	0.34	24/32 (74.0)	3/4 (75.0)	0.99	7/15 (46.7)	20/37 (54.1)	0.63
Clinical pregnancy^f	1–3	155/402 (38.5)	82/190 (43.1)	0.30	96/227 (42.3)	9/19 (47.4)	0.67	59/175 (33.7)	73/171 (42.6)	0.09
	1	37/163 (22.7)	9/40 (22.5)	0.98	10/52 (19.2)	1/5 (20.0)	0.97	27/111 (24.3)	8/35 (22.9)	0.86
	2	93/192 (48.4)	53/109 (48.6)	0.98	68/143 (47.6)	5/10 (50.0)	0.88	25/49 (51.0)	48/99 (48.5)	0.77
	3	25/47 (53.2)	20/41 (48.8)	0.68	18/32 (56.3)	3/4 (75.0)	0.47	7/15 (46.7)	17/37 (45.9)	0.96
Live birth^g	1–3	113/371 (30.5)	50/164 (30.5)	0.99	68/208 (32.7)	7/17 (41.2)	0.48	45/163 (27.6)	43/147 (29.3)	0.75
	1	27/153 (17.6)	5/38 (13.2)	0.51	7/49 (14.3)	1/5 (20.0)	0.73	20/104 (19.2)	4/33 (12.1)	0.35
	2	69/172 (40.1)	33/93 (35.5)	0.46	48/127 (37.8)	3/8 (37.5)	0.98	21/45 (46.7)	30/85 (35.3)	0.21
	3	17/46 (37.0)	12/33 (36.4)	0.96	13/32 (40.6)	3/4 (75.0)	0.19	4/14 (28.6)	9/29 (31.0)	0.87

Values are number positive/total number (percentage)
^aNumber of embryos transferred
^bDifference between patient oocytes and donor oocytes were determined by Chi-2 test for the complete cohort
^cDifference between patient oocytes and donor oocytes were determined by Chi-2 test for subjects ≤ 37 years
^dDifference between patient oocytes and donor oocytes were determined by Chi-2 test for subjects ≥ 38 years
^ePositive implantation was determined by β-hCG serum levels > 10 mg/dL at Day 14 after transfer
^fPositive clinical pregnancy was confirmed by the presence of a fetal heartbeat at week 6–8 (ultrasound)
^gPositive pregnancy was defined as a live birth