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Clinical and Translational Medicine

Table 4 Risk factors for over-all survival

From: Prediction of hepatic metastasis and relapse in colorectal cancers based on concordance analyses with liver fibrosis scores

Variables

Univariate analysis

Multivariate analysis

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

Liver fibrosis score

 NFS

1.772

1.307–2.403

< 0.001

1.683

1.22–2.312

0.001

 FIB4

1.487

1.165–1.899

0.001

1.453

1.12–1.878

0.004

 APRI

1.652

0.938–2.912

0.082

   

 Male gender

1.57

1.132–2.179

0.007

1.518

1.09–2.113

0.013

 Age > 70

1.834

1.315–2.560

< 0.001

1.784

1.25–2.540

0.01

T stage

 T1

Reference

  

Reference

  

 T2

1.502

0.77–2.927

0.233

1.471

0.75–2.870

0.258

 T3

2.025

0.956–4.288

0.065

1.571

0.72–3.391

0.25

 T4

2.647

1.419–4.938

0.002

2.012

1.06–3.792

0.031

N stage

 N0

Reference

  

Reference

  

 N1

1.446

1.026–2.038

0.035

1.287

0.9–1.821

0.153

 N2

1.017

0.608–1.699

0.95

1.016

0.60–1.703

0.951

Location

 Right-sided colon

Reference

  

Reference

  

 Left-sided colon

0.542

0.343–0.856

0.009

0.044

0.39–0.988

0.151

 Rectum

0.526

0.374–0.740

< 0.001

0.718

0.48–1.053

0.09

Lymph node examined

1.369

0.946–1.981

0.096

   

Mucinous Adenocarcinoma

1.667

1.034–2.688

0.036

1.323

0.81–2.161

0.264

Perineural invasion

1.169

0.76–1.776

0.464

   

Vascular invasion

1.367

0.95–1.956

0.088

   

Adjuvant therapy

2.418

1.68–3.461

< 0.001

2.301

1.57–3.358

< 0.001

Diabetes mellitus

1.003

0.60–1.656

0.991

   

Obesity (BMI > 25)

1.296

0.93–1.799

0.12

   
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