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Fig. 7 | Clinical and Translational Medicine

Fig. 7

From: PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma

Fig. 7

Effect of the PI3K inhibitor on the phosphorylation of nuclear signaling transcription factors in the H2O2-U937 cell model. a The expression of nuclear signaling transcription factors (p-NF-κB, p-c-FOS, and p-c-JUN) in the H2O2-U937 cell model was analyzed by western blotting. b Quantitative densitometric analysis of immunoreactive bands showed that p-NF-κB was most strongly inhibited by the combination of LY294002 and dexamethasone. p-c-FOS and p-c-JUN were most strongly inhibited by the combination of either BEZ235 or LY294002 with dexamethasone. Representative data from at least 3 independent experiments are shown (*p < 0.05; **p < 0.01, ns: nonsignificant. Each experiment was repeated at least three times)

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