TY - JOUR AU - Zhao, Hongyu AU - Wang, Yunfei AU - Yang, Chao AU - Zhou, Junhu AU - Wang, Lin AU - Yi, Kaikai AU - Li, Yansheng AU - wang, Qixue AU - Shi, Jin AU - Kang, Chunsheng AU - Zeng, Liang PY - 2020 DA - 2020/01/28 TI - EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression JO - Clinical and Translational Medicine SP - 10 VL - 9 IS - 1 AB - The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone acetylation is important for chromatin structure and function. However, the role and biological function of H2AZK4/7AC in tumours have not yet been clarified. SN - 2001-1326 UR - https://doi.org/10.1186/s40169-020-0260-7 DO - 10.1186/s40169-020-0260-7 ID - Zhao2020 ER -