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Clinical and Translational Medicine
Fig. 4 | Clinical and Translational Medicine

Fig. 4

From: Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction

Fig. 4

Core regulatory network and significant imprinted genes of FGR. a Volcano plot of the differentially expressed lncRNAs (216 up-regulated and 79 down-regulated). b Predicted cis-regulatory relationships among the differentially expressed protein-coding genes and lncRNAs. c Representative trans-regulatory relationships among the top 35 differentially expressed protein-coding gene and lncRNAs. d Regulatory network among the differentially expressed protein-coding genes, lncRNAs, and miRNAs after screening with the correlation coefficient (> 0.9). e PCC plots of all differentially expressed lncRNAs, protein-coding genes, and miRNAs. DEG, differentially expressed genes. PPI, protein–protein interaction. f Circos plot of all differentially expressed protein-coding genes, lncRNAs, and miRNAs on human chromosomes. g Imprinted genes collected from the Gene imprint and Otago databases. h GSEA plot of all imprinted genes in FGR and control umbilical cord blood samples. i Six imprinted genes (Col9a3, Dlk1, Fuca1, Lilrb4, Sfrp2, and Ventx) significantly differentially expressed in umbilical cord blood of FGR versus control

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