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Clinical and Translational Medicine
Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: Whole-transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction

Fig. 2

Differentially expressed protein-coding genes and physiological functional signaling pathways. a Volcano plot of the differentially expressed protein-coding genes (115 up-regulated and 224 down-regulated). b GO term enrichment of the down-regulated differentially expressed protein-coding genes. Green, molecular function. Blue, cellular component. Red, biological process. c Signaling pathway enrichment of the down-regulated differentially expressed protein-coding genes. d GO term enrichment of the up-regulated differentially expressed protein-coding genes. e Signaling pathway enrichment of the up-regulated differentially expressed protein-coding genes. f–h GSEA plots of FGR-related adult diseases, including metabolism (f), neural system (g), and cardiac system (h). i GSEA plots of predictive FGR-related diseases, including immune system (left panel) and oxidative phosphorylation (right panel)

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