Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients

Clinical and Translational Medicine

Table 3 Nonsynonymous SNPs predicted with SIFT, Polyphen, I-Mutant and PHD-SNP programs, chosen SNPs with PSIC SD range (1–0.99) and Tolerance Index equal (0.009)

SNP ID	Protein ID	Amino acid change	SIFT		Polyphen		I Mutant
SNP ID	Protein ID	Amino acid change	SIFT prediction	SIFT score	Polyphen prediction	Polyphen score	SVM2 prediction effect	DDG	RI
rs72551364	ENSP00000287820	R425C	Deleterious	0	Probably damaging	1	Decrease	− 2.38	7
rs72551364	ENSP00000312472	R397C	Deleterious	0	Probably damaging	1	Decrease	− 0.67	7
rs72551364	ENSP00000380205	R397C	Deleterious	0	Probably damaging.	1	Decrease	− 0.67	7
rs72551364	ENSP00000380207	R397C	Deleterious	0	Probably damaging	1	Decrease	− 0.67	7
rs72551364	ENSP00000380210	R397C	Deleterious	0	Probably damaging	1	Decrease	− 0.67	7
rs72551364	ENSP00000380221	R403C	Deleterious	0	Benign	0.356	Decrease	− 0.85	7
rs121909244	ENSP00000287820	P495L	Deleterious	0.001	Benign	0.356	Decrease	− 0.19	4
rs121909244	ENSP00000312472	P467L	Deleterious	0.001	Probably damaging	1	Decrease	− 0.14	4
rs121909244	ENSP00000380205	P467L	Deleterious	0.001	Probably damaging	1	Decrease	− 0.14	4
rs121909244	ENSP00000380207	P467L	Deleterious	0.001	Probably damaging	1	Decrease	− 0.14	4
rs121909244	ENSP00000380210	P467L	Deleterious	0.001	Probably damaging	1	Decrease	− 0.14	4
rs121909244	ENSP00000380221	P473L	Deleterious	0.001	Probably damaging	1	Decrease	0.46	4