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Table 3 Nonsynonymous SNPs predicted with SIFT, Polyphen, I-Mutant and PHD-SNP programs, chosen SNPs with PSIC SD range (1–0.99) and Tolerance Index equal (0.009)

From: Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients

SNP IDProtein IDAmino acid changeSIFTPolyphenI Mutant
SIFT predictionSIFT scorePolyphen predictionPolyphen scoreSVM2 prediction effectDDGRI
rs72551364ENSP00000287820R425CDeleterious0Probably damaging1Decrease− 2.387
rs72551364ENSP00000312472R397CDeleterious0Probably damaging1Decrease− 0.677
rs72551364ENSP00000380205R397CDeleterious0Probably damaging.1Decrease− 0.677
rs72551364ENSP00000380207R397CDeleterious0Probably damaging1Decrease− 0.677
rs72551364ENSP00000380210R397CDeleterious0Probably damaging1Decrease− 0.677
rs72551364ENSP00000380221R403CDeleterious0Benign0.356Decrease− 0.857
rs121909244ENSP00000287820P495LDeleterious0.001Benign0.356Decrease− 0.194
rs121909244ENSP00000312472P467LDeleterious0.001Probably damaging1Decrease− 0.144
rs121909244ENSP00000380205P467LDeleterious0.001Probably damaging1Decrease− 0.144
rs121909244ENSP00000380207P467LDeleterious0.001Probably damaging1Decrease− 0.144
rs121909244ENSP00000380210P467LDeleterious0.001Probably damaging1Decrease− 0.144
rs121909244ENSP00000380221P473LDeleterious0.001Probably damaging1Decrease0.464