Unveiling ncRNA regulatory axes in atherosclerosis progression

Clinical and Translational Medicine

Table 3 lncRNA:miRNA:mRNA axis in atherosclerosis progression

lncRNA	Sponged miRNA	Target mRNA	Regulated pathway in ATH progression	References
MALAT1	miR-204	SMAD4	Osteogenic differentiation in CAVD	[161]
MALAT1	miR-320a	FOXM1	Proliferation of HUVECs	[162]
MIAT	miR-181b	STAT3	Proliferation and apoptosis in HA-VSMC cells	[163]
MIAT	miR-149-5p	CD47	Promoted atherosclerosis progression	[164]
MEG3	miR-26a	SMAD1	Proliferation of vascular smooth muscle cells	[165]
MEG3	miR-223	NLRP3	Pyroptosis in HAEC cells	[166]
DIGIT	miR-134	Bmi-1	Viability, migration and apoptosis of HMEC-1 cells	[167]
GSA5	miR-221	MMPs	Inflammatory response in THP-1 cells	[168]
Linc00657	miR-590-3p	HIF-1α	Angiogenesis	[169]
TUG1	miR-204-5p	Runx2	Osteoblast differentiation in human aortic VICs	[170]
Linc00299	miR-490-3p	AURKA	Proliferation of vascular smooth muscle cells and HUVECs	[171]
UCA1	miR-26a	PTEN	Proliferation of vascular smooth muscle cells	[172]
Linc00305	miR-136	n.d.	Proliferation and apoptosis of HUVECs	[173]
MKI67IP-3	Let-7e	IκBβ	Inflammatory response in VECs	[174]
H19	miR-148b	WNT1	Proliferation and apoptosis of HA-VSMCs	[175]
RNCR3	miR-185-5p	KLF2	Proliferation of ECs and VSMCs	[176]

For each lncRNA shown are also a sponged miRNA and one mRNA target of this last, as well as the effect of the RNA network on ATH progression. n.d. not determined
Abbreviations of the tissues, cells and cell lines used in the works referenced: CAVD calcified aortic valve disease, HA-VSMCs human aorta vascular smooth muscle cells, HUVECs human umbilical vein endothelial cells, HAECs human aortic endothelial cells, HMEC-1 human microvascular endothelial cell line, VICs human valve interstitial cells, VECs vascular endothelial cells