From: Unveiling ncRNA regulatory axes in atherosclerosis progression
miRNA | Target mRNA/sa | Effect of miRNAs on ATH progression | References |
---|---|---|---|
miR-9 | Oxidized low-density lipoprotein (lectin-like) receptor 1 (OLR1) | ApoE-null mice (U/R protective) | [95] |
miR-23a-5p | ATP-binding cassette transporter A1/G1 ABCA1/G1 | U/R promotes macrophage-derived foam cell formation | [96] |
miR-23b | Forkhead Box O4 (FoxO4) | U/R inhibited VSMC proliferation and migration | [97] |
miR-25-3p | A disintegrin and metalloprotease 10 (Adam10) | ApoE-null mice (U/R protective) | [98] |
miR-30-3p | Transcription factor 21 (TCF21) | U/R increases viability of HUVEC cells | [99] |
miR-34a | BCL2 apoptosis regulator (BCL2) | D/R facilitated growth and blocked apoptosis in HAECs | [100] |
miR-98 | Receptor for ox-LDL 1 (LOX-1) | D/R inhibited foam cell formation and lipid accumulation in aortas of ApoE-null mice | [101] |
miR-99a-5p | Homeobox A1 (HOXA1) | U/R inhibits proliferation and invasion of ASMCs | [102] |
miR-103 | Phosphatase and tensin homolog (PTEN) | D/R suppressed inflammation and ERS in ECs from ApoE-null mice | [103] |
miR-124 | MCL-1 apoptosis regulator (MCL-1) | U/R represses viability, migration and capillary structure formation in HMEC-1 cells. Sponged by lncRNA HULC | [104] |
miR-135b | Erythropoietin receptor (EPOR) | C57BL/6J male mice (D/R protective) | [105] |
miR-142-3p | Rapamycin-insensitive companion of MTOR (Rictor) | D/R inhibited ECs apoptosis and ATH development in HAECs | [106] |
miR-223 | Insulin growth factor-1 receptor (IGF-1R) | U/R inhibits foam cell formation in VSMCs of human ATH patients | [107] |
miR-338-3p | BMP and activin membrane-bound inhibitor (BAMBI) | D/R promoted viability and inhibited apoptosis in ox-LDL-induced HUVECs | [108] |
miR-365b-3p | A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) | U/R attenuated PDGF-BB-induced proliferation and migration of HCASMCs | [109] |
miR-370 | Forkhead Box 1 (FOXO1) | U/R promotes invasion and proliferation of HUVECs | [110] |
miR-370 | Toll-like receptor 4 (TLR4) | U/R inhibits IL-6 and IL-1β expression and ROS levels in THP-1 cells | [111] |
miR-451 | 14-3-3 ζ (YWHAZ) | U/R improves intimal thickening in rats following vascular injury | [112] |
miR-590 | Toll-like receptor 4 (TLR4) | U/R inhibited atherosclerotic lesion in ApoE-null mice and HAECS | [113] |
miR-647 | Phosphatase and tensin homolog (PTEN) | Upregulated in HA-VSMCs | [114] |