Fig. 2

Impact of alternatively expressed 3′UTRs on their interaction with miRNAs. Shown are changes in the structure of the 3′UTRs with the potential to impact on the binding of specific miRNAs. 1. The existence of alternative polyadenylation signals originate 3′UTRs of different lengths and different potential for miRNA binding. 2. Alternative exons encoding different 3′UTRs differ in their potential for miRNA binding. 3. Exonic switch. In the case of the Cd34 gene, an internal cryptic splice site (CSS) activates two different stop codons and generates two different exons 8, with the consequence that in one Cd34 isoform the binding site for a number of miRNAs is located in the 3′UTR, while in the other isoform it is located inside the CDS (taken from [87])