A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia

Clinical and Translational Medicine

Table 2 Multi-trait analysis results of GWAS for BMD, bone area and SCZ (P value < 1.00 × 10⁻⁵)

Phenotype	SNP	MAF	Beta^a	P value^a	Gene
Hip total area vs. SCZ
SCZ	rs17018359	0.23	− 0.101	3.44 × 10⁻⁶	CTNNA2
SCZ	rs1561296	0.27	− 0.093	7.01 × 10⁻⁶	LOC101927741/SPATS2L
Hip total BMD vs. SCZ
SCZ	rs17018359	0.23	− 0.102	3.04 × 10⁻⁶	CTNNA2
SCZ	rs1561296	0.27	− 0.093	7.53 × 10⁻⁶	LOC101927741/SPATS2L
Hip neck Area vs. SCZ
SCZ	rs17018359	0.23	− 0.103	2.81 × 10⁻⁶	CTNNA2
SCZ	rs1561296	0.27	− 0.093	7.38 × 10⁻⁶	LOC101927741/SPATS2L
Hip neck BMD vs. SCZ
Hip neck BMD	rs11259498	0.09	− 0.306	1.06 × 10⁻⁶	LOC105376431 NMT2
SCZ	rs17018359	0.23	− 0.102	3.09 × 10⁻⁶	CTNNA2
SCZ	rs1561296	0.27	− 0.093	7.24 × 10⁻⁶	LOC101927741/SPATS2L
Spine area vs. SCZ
Spine area	rs174577	0.41	− 0.175	2.66 × 10⁻⁷
Spine area	rs174570	0.41	− 0.172	4.85 × 10⁻⁷
Spine area	rs174547	0.42	− 0.170	5.31 × 10⁻⁷
Spine area	rs8019455	0.22	− 0.189	2.87 × 10⁻⁶
SCZ	rs17018359	0.23	− 0.099	4.54 × 10⁻⁶
Spine BMD vs. SCZ
Spine BMD	rs4721564	0.38	− 0.161	8.37 × 10⁻⁶
SCZ	rs17018359	0.23	− 0.102	2.24 × 10⁻⁶	CTNNA2
SCZ	rs16945898	0.1	− 0.140	4.19 × 10⁻⁶
SCZ	rs1561296	0.27	− 0.092	6.70 × 10⁻⁶	LOC101927741/SPATS2L
SCZ	rs1791244	0.43	− 0.083	7.17 × 10⁻⁶	MIR924HG
Ulna & radius area vs. SCZ
Ulna & radius area	rs742715	0.43	− 0.180	9.30 × 10⁻⁷	LOC105377865
SCZ	rs17018359	0.23	− 0.102	3.05 × 10⁻⁶	CTNNA2
SCZ	rs1561296	0.27	− 0.093	7.55 × 10⁻⁶	LOC101927741/SPATS2L