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Table 2 Univariate and multivariate Cox analyses of OS in the whole cohort

From: Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer

Variable

University analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

CEA level

 

< 0.001

 

< 0.001

 Normal

Reference

 

Reference

 

 Elevated

3.414 (2.754–4.231)

 

2.417 (1.928–3.030)

 

Basophil level

 

< 0.001

 

< 0.001

 ≥ 0.025*109/L

Reference

 

Reference

 

 < 0.025*109/L

2.150 (1.746–2.648)

 

1.748 (1.410–2.168)

 

T stage

 

< 0.001

 

0.038

 T1

Reference

 

Reference

 

 T2

0.882 (0.375–2.074)

0.773

0.553 (0.232–1.318)

0.181

 T3

2.201 (1.013–4.784)

0.046

0.945 (0.419–2.129)

0.891

 T4a

3.638 (1.716–7.717)

0.001

1.136 (0.510–2.531)

0.755

 T4b

6.344 (2.731–14.736)

< 0.001

1.312 (0.532–3.232)

0.555

N stage

 

< 0.001

 

<0.001

 N0

Reference

 

Reference

 

 N1a

1.744 (1.120–2.717)

0.014

1.610 (1.008–2.574)

0.046

 N1b

2.094 (1.407–3.116)

< 0.001

2.124 (1.384–3.259)

0.001

 N1c

3.626 (2.584–5.089)

< 0.001

2.634 (1.811–3.830)

<0.001

 N2a

3.995 (2.883–5.536)

< 0.001

2.764 (1.891–4.041)

<0.001

 N2b

6.292 (4.609–8.591)

< 0.001

4.590 (3.150–6.687)

<0.001

Gender

 

0.351

  

 Male

Reference

   

 Female

1.104 (0.897–1.358)

   

Histology

 

< 0.001

 

0.447

 Adenocarcinoma

Reference

 

Reference

 

 Mucinous adenocarcinoma

1.292 (0.996–1.676)

0.054

1.125 (0.833–1.519)

0.443

 Signet ring cell carcinoma

3.166 (1.881–5.330)

< 0.001

1.402 (0.788–2.493)

0.250

Tumor location

 

< 0.001

 

0.005

 Right colon

Reference

 

Reference

 

 Left colon

0.555 (0.399–0.774)

0.001

0.590 (0.420–0.829)

0.002

 Rectum

0.632 (0.503–0.795)

< 0.001

0.742 (0.584–0.944)

0.015

Tumor grade

 

< 0.001

 

0.119

 Well

Reference

 

Reference

 

 Moderate

2.123 (1.126–4.004)

0.020

1.874 (0.986–3.564)

0.055

 Poor

3.590 (1.890–6.819)

< 0.001

2.013 (1.036–3.910)

0.039

 Venous invasion

 

< 0.001

 

0.033

 No

Reference

 

Reference

 

 Yes

2.165 (1.762–2.660)

 

1.290 (1.021–1.630)

 

Perineural invasion

 

< 0.001

 

0.164

 No

Reference

 

Reference

 

 Yes

1.867 (1.509–2.310)

 

1.181 (0.934–1.493)

 

Lymph nodes dissected in total

 

0.325

  

  < 12

Reference

   

  ≥ 12

1.140 (0.878–1.480)

   

Age (years)

 

< 0.001

 

< 0.001

  < 65

Reference

 

Reference

 

  ≥ 65

1.849 (1.501–2.276)

 

1.658 (1.329–2.068)

 

Adjuvant chemotherapy

 

0.111

 

< 0.001

 No

Reference

 

Reference

 

 Yes

0.813 (0.631–1.049)

 

0.491 (0.369–0.652)