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Table 2 Univariate and multivariate Cox analyses of OS in the whole cohort

From: Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer

VariableUniversity analysisMultivariate analysis
HR (95% CI)PHR (95% CI)P
CEA level < 0.001 < 0.001
 NormalReference Reference 
 Elevated3.414 (2.754–4.231) 2.417 (1.928–3.030) 
Basophil level < 0.001 < 0.001
 ≥ 0.025*109/LReference Reference 
 < 0.025*109/L2.150 (1.746–2.648) 1.748 (1.410–2.168) 
T stage < 0.001 0.038
 T1Reference Reference 
 T20.882 (0.375–2.074)0.7730.553 (0.232–1.318)0.181
 T32.201 (1.013–4.784)0.0460.945 (0.419–2.129)0.891
 T4a3.638 (1.716–7.717)0.0011.136 (0.510–2.531)0.755
 T4b6.344 (2.731–14.736)< 0.0011.312 (0.532–3.232)0.555
N stage < 0.001 <0.001
 N0Reference Reference 
 N1a1.744 (1.120–2.717)0.0141.610 (1.008–2.574)0.046
 N1b2.094 (1.407–3.116)< 0.0012.124 (1.384–3.259)0.001
 N1c3.626 (2.584–5.089)< 0.0012.634 (1.811–3.830)<0.001
 N2a3.995 (2.883–5.536)< 0.0012.764 (1.891–4.041)<0.001
 N2b6.292 (4.609–8.591)< 0.0014.590 (3.150–6.687)<0.001
Gender 0.351  
 MaleReference   
 Female1.104 (0.897–1.358)   
Histology < 0.001 0.447
 AdenocarcinomaReference Reference 
 Mucinous adenocarcinoma1.292 (0.996–1.676)0.0541.125 (0.833–1.519)0.443
 Signet ring cell carcinoma3.166 (1.881–5.330)< 0.0011.402 (0.788–2.493)0.250
Tumor location < 0.001 0.005
 Right colonReference Reference 
 Left colon0.555 (0.399–0.774)0.0010.590 (0.420–0.829)0.002
 Rectum0.632 (0.503–0.795)< 0.0010.742 (0.584–0.944)0.015
Tumor grade < 0.001 0.119
 WellReference Reference 
 Moderate2.123 (1.126–4.004)0.0201.874 (0.986–3.564)0.055
 Poor3.590 (1.890–6.819)< 0.0012.013 (1.036–3.910)0.039
 Venous invasion < 0.001 0.033
 NoReference Reference 
 Yes2.165 (1.762–2.660) 1.290 (1.021–1.630) 
Perineural invasion < 0.001 0.164
 NoReference Reference 
 Yes1.867 (1.509–2.310) 1.181 (0.934–1.493) 
Lymph nodes dissected in total 0.325  
  < 12Reference   
  ≥ 121.140 (0.878–1.480)   
Age (years) < 0.001 < 0.001
  < 65Reference Reference 
  ≥ 651.849 (1.501–2.276) 1.658 (1.329–2.068) 
Adjuvant chemotherapy 0.111 < 0.001
 NoReference Reference 
 Yes0.813 (0.631–1.049) 0.491 (0.369–0.652)