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Table 1 Univariate and multivariate Cox analyses of DFS in the whole cohort

From: Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer

VariableUniversity analysisMultivariate analysis
HR (95% CI)PHR (95% CI)P
CEA level < 0.001 < 0.001
 NormalReference Reference 
 Elevated2.439 (2.088–2.849) 1.879 (1.598–2.211) 
Basophil level < 0.001 < 0.001
 ≥ 0.025*109/LReference Reference 
 < 0.025*109/L2.381 (2.036–2.784) 2.197 (1.868–2.585) 
T stage < 0.001 0.025
 T1Reference Reference 
 T21.681 (0.907–3.115)0.0991.331 (0.713–2.485)0.369
 T32.854 (1.583–5.147)< 0.0011.727 (0.942–3.168)0.077
 T4a4.158 (2.341–7.387)< 0.0011.972 (1.082–3.595)0.027
 T4b5.164 (2.650–10.062)< 0.0012.058 (1.030–4.112)0.041
N stage < 0.001 < 0.001
 N0Reference Reference 
 N1a1.511 (1.118–2.042)0.0071.236 (0.902–1.693)0.188
 N1b2.099 (1.619–2.722)< 0.0011.907 (1.447–2.513)< 0.001
 N1c2.705 (2.122–3.446)< 0.0011.798 (1.385–2.334)< 0.001
 N2a2.699 (2.125–3.430)< 0.0011.848 (1.403–2.434)< 0.001
 N2b3.508 (2.778–4.430)< 0.0012.685 (2.040–3.535)< 0.001
Gender 0.382  
 MaleReference   
 Female0.932 (0.797–1.091)   
Histology 0.340  
 AdenocarcinomaReference   
 Mucinous adenocarcinoma1.023 (0.832–1.257)0.832  
 Signet ring cell carcinoma2.010 (1.255–3.218)0.004  
 Tumor location 0.431  
 Right colonReference   
 Left colon0.847 (0.658–1.089)0.195  
 Rectum0.935 (0.778–1.123)0.470  
Tumor grade < 0.001 0.128
 WellReference Reference 
 Moderate1.610 (1.090–2.378) 1.441 (0.971–2.140)0.070
 Poor2.287 (1.533–3.412) 1.523 (1.014–2.288)0.043
Venous invasion < 0.001 0.732
 NoReference Reference 
 Yes1.679 (1.434–1.965) 1.032 (0.862–1.235) 
Perineural invasion < 0.001 0.001
 NoReference Reference 
 Yes1.952 (1.663–2.291) 1.357 (1.136–1.620) 
Lymph nodes dissected in total 0.048 0.004
 < 12Reference Reference 
 ≥ 121.222 (1.002–1.491) 0.735 (0.596–0.905) 
Age (years) < 0.001 < 0.001
 < 65Reference Reference 
 ≥ 651.483 (1.264–1.740) 1.509 (1.277–1.783) 
Adjuvant chemotherapy 0.045 0.294
 NoReference Reference 
 Yes1.242 (1.005–1.534) 0.884 (0.702–1.113)