Variable | University analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
CEA level | < 0.001 | < 0.001 | ||
Normal | Reference | Reference | ||
Elevated | 2.439 (2.088–2.849) | 1.879 (1.598–2.211) | ||
Basophil level | < 0.001 | < 0.001 | ||
≥ 0.025*109/L | Reference | Reference | ||
< 0.025*109/L | 2.381 (2.036–2.784) | 2.197 (1.868–2.585) | ||
T stage | < 0.001 | 0.025 | ||
T1 | Reference | Reference | ||
T2 | 1.681 (0.907–3.115) | 0.099 | 1.331 (0.713–2.485) | 0.369 |
T3 | 2.854 (1.583–5.147) | < 0.001 | 1.727 (0.942–3.168) | 0.077 |
T4a | 4.158 (2.341–7.387) | < 0.001 | 1.972 (1.082–3.595) | 0.027 |
T4b | 5.164 (2.650–10.062) | < 0.001 | 2.058 (1.030–4.112) | 0.041 |
N stage | < 0.001 | < 0.001 | ||
N0 | Reference | Reference | ||
N1a | 1.511 (1.118–2.042) | 0.007 | 1.236 (0.902–1.693) | 0.188 |
N1b | 2.099 (1.619–2.722) | < 0.001 | 1.907 (1.447–2.513) | < 0.001 |
N1c | 2.705 (2.122–3.446) | < 0.001 | 1.798 (1.385–2.334) | < 0.001 |
N2a | 2.699 (2.125–3.430) | < 0.001 | 1.848 (1.403–2.434) | < 0.001 |
N2b | 3.508 (2.778–4.430) | < 0.001 | 2.685 (2.040–3.535) | < 0.001 |
Gender | 0.382 | |||
Male | Reference | |||
Female | 0.932 (0.797–1.091) | |||
Histology | 0.340 | |||
Adenocarcinoma | Reference | |||
Mucinous adenocarcinoma | 1.023 (0.832–1.257) | 0.832 | ||
Signet ring cell carcinoma | 2.010 (1.255–3.218) | 0.004 | ||
Tumor location | 0.431 | |||
Right colon | Reference | |||
Left colon | 0.847 (0.658–1.089) | 0.195 | ||
Rectum | 0.935 (0.778–1.123) | 0.470 | ||
Tumor grade | < 0.001 | 0.128 | ||
Well | Reference | Reference | ||
Moderate | 1.610 (1.090–2.378) | 1.441 (0.971–2.140) | 0.070 | |
Poor | 2.287 (1.533–3.412) | 1.523 (1.014–2.288) | 0.043 | |
Venous invasion | < 0.001 | 0.732 | ||
No | Reference | Reference | ||
Yes | 1.679 (1.434–1.965) | 1.032 (0.862–1.235) | ||
Perineural invasion | < 0.001 | 0.001 | ||
No | Reference | Reference | ||
Yes | 1.952 (1.663–2.291) | 1.357 (1.136–1.620) | ||
Lymph nodes dissected in total | 0.048 | 0.004 | ||
< 12 | Reference | Reference | ||
≥ 12 | 1.222 (1.002–1.491) | 0.735 (0.596–0.905) | ||
Age (years) | < 0.001 | < 0.001 | ||
< 65 | Reference | Reference | ||
≥ 65 | 1.483 (1.264–1.740) | 1.509 (1.277–1.783) | ||
Adjuvant chemotherapy | 0.045 | 0.294 | ||
No | Reference | Reference | ||
Yes | 1.242 (1.005–1.534) | 0.884 (0.702–1.113) |