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Table 1 Univariate and multivariate Cox analyses of DFS in the whole cohort

From: Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer

Variable

University analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

CEA level

 

< 0.001

 

< 0.001

 Normal

Reference

 

Reference

 

 Elevated

2.439 (2.088–2.849)

 

1.879 (1.598–2.211)

 

Basophil level

 

< 0.001

 

< 0.001

 ≥ 0.025*109/L

Reference

 

Reference

 

 < 0.025*109/L

2.381 (2.036–2.784)

 

2.197 (1.868–2.585)

 

T stage

 

< 0.001

 

0.025

 T1

Reference

 

Reference

 

 T2

1.681 (0.907–3.115)

0.099

1.331 (0.713–2.485)

0.369

 T3

2.854 (1.583–5.147)

< 0.001

1.727 (0.942–3.168)

0.077

 T4a

4.158 (2.341–7.387)

< 0.001

1.972 (1.082–3.595)

0.027

 T4b

5.164 (2.650–10.062)

< 0.001

2.058 (1.030–4.112)

0.041

N stage

 

< 0.001

 

< 0.001

 N0

Reference

 

Reference

 

 N1a

1.511 (1.118–2.042)

0.007

1.236 (0.902–1.693)

0.188

 N1b

2.099 (1.619–2.722)

< 0.001

1.907 (1.447–2.513)

< 0.001

 N1c

2.705 (2.122–3.446)

< 0.001

1.798 (1.385–2.334)

< 0.001

 N2a

2.699 (2.125–3.430)

< 0.001

1.848 (1.403–2.434)

< 0.001

 N2b

3.508 (2.778–4.430)

< 0.001

2.685 (2.040–3.535)

< 0.001

Gender

 

0.382

  

 Male

Reference

   

 Female

0.932 (0.797–1.091)

   

Histology

 

0.340

  

 Adenocarcinoma

Reference

   

 Mucinous adenocarcinoma

1.023 (0.832–1.257)

0.832

  

 Signet ring cell carcinoma

2.010 (1.255–3.218)

0.004

  

 Tumor location

 

0.431

  

 Right colon

Reference

   

 Left colon

0.847 (0.658–1.089)

0.195

  

 Rectum

0.935 (0.778–1.123)

0.470

  

Tumor grade

 

< 0.001

 

0.128

 Well

Reference

 

Reference

 

 Moderate

1.610 (1.090–2.378)

 

1.441 (0.971–2.140)

0.070

 Poor

2.287 (1.533–3.412)

 

1.523 (1.014–2.288)

0.043

Venous invasion

 

< 0.001

 

0.732

 No

Reference

 

Reference

 

 Yes

1.679 (1.434–1.965)

 

1.032 (0.862–1.235)

 

Perineural invasion

 

< 0.001

 

0.001

 No

Reference

 

Reference

 

 Yes

1.952 (1.663–2.291)

 

1.357 (1.136–1.620)

 

Lymph nodes dissected in total

 

0.048

 

0.004

 < 12

Reference

 

Reference

 

 ≥ 12

1.222 (1.002–1.491)

 

0.735 (0.596–0.905)

 

Age (years)

 

< 0.001

 

< 0.001

 < 65

Reference

 

Reference

 

 ≥ 65

1.483 (1.264–1.740)

 

1.509 (1.277–1.783)

 

Adjuvant chemotherapy

 

0.045

 

0.294

 No

Reference

 

Reference

 

 Yes

1.242 (1.005–1.534)

 

0.884 (0.702–1.113)