Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD)

Clinical and Translational Medicine

Table 1 Top clustered genes in the PPI networks. The seed genes with the highest density in PP networks are shown

GOID	Betweenness centrality	Closeness centrality	Degree	GOID	Betweenness centrality	Closeness centrality	Degree
Normal vs. MCT				HSF1	0.002468	0.285681	17
EDN1	0.412698	0.313043	3	NRCAM	0.001105	0.25658	13
MCT vs. SC				PRMT5	0.000581	0.296164	17
EGFR	0.017832	0.371711	149	POLR3C	3.92E-05	0.265655	17
RPL35	5.85E-05	0.30435847	73	SEMA3A	3.9E-05	0.28154	16
COPA	0.00661	0.299735	54	TAF9B	0.00086	0.274302	15
PMF1	1.41E-05	0.309089	49	PIAS4	0.000677	0.299916	15
ARF6	0.006571	0.317375	45	THRB	0.000456	0.312586	13
FBXW11	0.002383	0.324162	44	DCAF7	0.000292	0.276992	12
SMURF2	0.003544	0.323445	40	EIF1	1.64E-05	0.240752	12
WWTR1	0.004166	0.318269	35	GSN	0.004329	0.284374	11
CACNB2	0.001283	0.313691	34	OCLN	0.001005	0.269397	11
TBL1X	0.001139	0.317051	33	AES	7.63E-05	0.308475	11
CUL3	0.001145	0.302286	28	ATP6	3.7E-07	0.186567	11
RPP30	0.000402	0.250681	28	ALDOA	0.001615	0.264891	4
AP1M2	5.86E-05	0.281063	26	HSD17B8	0.666667	1	3
TGFB2	0.002654	0.314127	25	SC vs. LC
PHAX	0.000336	0.294655	23	NCBP1	0.153881	0.26259	17
FABP4	0.000212	0.297939	23	KDELR2	0.01875	0.533333	7
SEC23A	0.001501	0.258339	22	FOXO1	0.152968	0.264493	5
CXCL9	6.9E-05	0.269514	21	EDN1	0.121988	0.302905	7
ND2	5E-05	0.215126	21	PSMA5	0.066667	0.769231	7
CTF1	0.000322	0.267398	19	ITGB5	0.134354	0.25	5
CITED2	9.8E-05	0.289845	19	PPIE	0.105023	0.216617	7