The dual functional role of MicroRNA-18a (miR-18a) in cancer development

Clinical and Translational Medicine

Table 2 The dual function of miR-18a in human cancers and miR-18a clinical applications

Cancer type	Expression status in cancer tissues and cell lines	Level in peripheral blood (plasma/serum)	Effect on oncogenesis	Potential clinical applications	Sample	Result	References
Non-small-cell lung cancer	Overexpressed	Increased	Promotes	Diagnostic marker	Peripheral blood miR-18a	AUC = 0.76 (95% CI 0.67–0.86)	[54, 81]
Non-small-cell lung cancer	Overexpressed	Increased	Promotes	Chemoradiotherapy sensitizer	–	–	[85]
Cervical cancer	Overexpressed	Unknown	Promotes	Unknown	Unknown	Unknown	[56]
Prostate cancer	Overexpressed	Unknown	Promotes	Unknown	Unknown	Unknown	[58]
Gastric cancer	Overexpressed	Unknown	Promotes	Diagnostic marker	Plasma miR-18a	AUC = 0.8059	[61, 82]
Colorectal cancer	Overexpressed	Increased	Inhibits	Diagnostic marker	Serum miR-18a	2.229-fold change (p = 0.038)	[68, 83]
Breast cancer	Overexpressed	Increased	Inhibits	Diagnostic marker	Serum miR-18a	19.00% change (p = 0.04)	[69, 84]
Pancreatic cancer	Overexpressed	Increased	Inhibits	Unknown	Unknown	Unknown	[75]
Hepatocellular carcinoma	Overexpressed	Increased	Unknown	Drug target	Unknown	Unknown	[86]