Fig. 1

The human miR-17-92 gene and its homologs. The gene structure of the human miR-17-92 cluster (located on chromosome 13) and its two mammalian paralogs: the miR-106b-25 cluster (located on human chromosome 7) and the miR-106a-363 cluster (located on the X chromosome). The miRNAs encoded by the 3 clusters are categorized into the miR-17 family (miR-17, miR-20a, miR-106b, miR-93, miR-106a and miR-20b), the miR-18a family (miR-18a and miR-18b), the miR-19 family (miR-19a, miR-19b-1 and miR-19b-2) and the miR-92 family (miR-92a-1, miR-25, miR-92a-2 and miR-363)