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Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR

Fig. 2

RANKL promotes migration of gastric cancer cells by activating EGFR pathway. a After treatment with RANKL at different time points, the HER family members showed persistent or transient phosphorylation activation by western blot. b RANKL can up-regulate the levels of P-EGFR, P-AKT and P-ERK. However, this effect can be counteracted by transfection of siEGFR. c, d The transwell assay and wound healing assay results showed that the RANKL can up-regulate the number of cell migration increased significantly. Same as above, this effect can be counteracted by transfection of siEGFR. Data are mean ± SD in three independent experiment. (**p < 0.01)

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