Skip to main content

Advertisement

Table 3 Univariate and multivariate Cox regression for all-cause mortality based on treatment modalities and metastatic sites

From: Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study of 16,643 patients

GroupsVariablesLevelnUnivariateMultivariate
HR (95% CI)p valueHR (95% CI)p value
Bone-only
(n = 14,872)
SurgeryNo/unknown13,4751 1 
Endoscopic therapy11910.975 (0.898–1.058)0.5391.106 (1.016–1.204)0.020
RP2060.187 (0.128–0.274)< 0.0010.339 (0.231–0.495)< 0.001
RTNo/unknown11,5841 1 
EBRT31940.898 (0.850–0.949)< 0.0010.954 (0.902–1.009)0.097
Brachytherapy940.396 (0.272–0.578)< 0.0010.567 (0.388–0.829)0.003
ChemoNo/unknown13,0151 1 
Yes18570.761 (0.700–0.827)< 0.0010.850 (0.781–0.924)< 0.001
Bone and lung
(n = 976)
SurgeryNo/unknown8991   
Endoscopic therapy720.844 (0.609–1.169)0.308  
RP5  
RTNo/unknown7581   
EBRT2160.915 (0.744–1.125)0.400  
Brachytherapy2  
ChemoNo/unknown8081 1 
Yes1680.643 (0.483–0.855)0.0020.737 (0.552–0.984)0.039
Bone and liver
(n = 414)
SurgeryNo/unknown3551   
Endoscopic therapy570.970 (0.707–1.332)0.852  
RP2  
RTNo/unknown3331   
EBRT800.898 (0.673–1.198)0.464  
Brachytherapy1  
ChemoNo/unknown3061 1 
Yes1080.629 (0.477–0.830)0.0010.651 (0.491–0.864)0.003
Bone and brain
(n = 126)
SurgeryNo/unknown1221   
Endoscopic therapy2  
RP2  
RTNo/unknown781   
EBRT461.015 (0.668–1.541)0.944  
Brachytherapy2  
ChemoNo/unknown1071   
Yes190.577 (0.314–1.062)0.077  
Bone and ≥ 2 other sites
(n = 255)
SurgeryNo/unknown2341   
Endoscopic therapy210.872 (0.474–1.606)0.661  
RTNo/unknown1841   
EBRT711.007 (0.730–1.390)0.965  
ChemoNo/unknown1911   
Yes641.009 (0.709–1.43600)0.959  
  1. Multivariate analysis was adjusted for age, marriage, race, PSA, and Gleason score