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Clinical and Translational Medicine
Fig. 3 | Clinical and Translational Medicine

Fig. 3

From: New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota

Fig. 3

MUC1 mucin: a molecule with complex functions. MUC1 mucin can be characterized as a pan-tumor antigen, associated with adenocarcinomas, lymphomas and leukemias, where it plays a significant role in proliferation, metabolism and metastasis of tumor cells. In addition, MUC1 is also expressed on immune cells such as T cells, B cells, dendritic cells and monocytes. On T cells, MUC1 is putatively a checkpoint molecule and serves as a co-inhibitory molecule. The function of MUC1 on other immune cells is not clear yet. MUC1 mucin exemplifies the level of complexity present within the TME and consequently the development of cancer therapeutics

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