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Table 5 Let-7 regulators on transcriptional, post-transcriptional, and functional levels

From: Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Let-7 regulation

Inhibitor

Family member

Context

Mechanism

JARID1B [91]

let-7e

Breast cancer

 

p53 mutant [81]

let-7i

Lung cancer

 

DCMAKL-1 [125]

let-7a

Colorectal cancer

 

MYC [105]

let-7a-1, f-1, d

Hepatocellular carcinoma

 

OCT-1 [156]

let-7g

Aorta smooth muscle cells

 

COX2* [161]

let-7b

Urothelial cancer

 

TWIST [106]

let-7i

Head and neck cancer

 

BMI1 [106, 162]

let-7i

Head and neck cancer

 

KDM2B [163]

let-7b

Embryonic fibroblasts

Promoter methylation

LIN28 [110, 113, 133]

let-7a1, a2, b, c, d, e, g, f1, f2, I, Mir-98

Mouse ESCs, Hela cells

 

STAT3 [85]

let-7a

Ewing sarcoma

NFkB activation

NFkB [119]

let-7a, b, c, d, f

Breast cancer

LIN28 up-regulation

MiR-107 [126]

let-7a

Breast cancer

 

LncRNA H19 [49]

let-7a, b

Breast cancer

 

Link-ROR [127]

let-7i, b, e, c

Pancreatic cancer

 

IMP2 [130]

Seed

Glioblastoma stem cells

Target stabilization

LncRNA RSU1P2 [128]

let-7a

Cervical caner

 

ADAR1 [124]

let-7d

Leukemia stem cells

 

LncRNA CCR492 [129]

Seed

Mouse embryonic fibroblast

 

eEBPa [164]

let-7a2

Lung cancer

 

SNP rs10877887 [107]

let-7i

Cervical cancer

 

P53 [104]

let-7a, b

Colon cancer

Cellular stress

Activator

Family member

Context

 

ZEB1 [97]

let-7e

Esophageal cancer

 

OCT4 [103]

let-7a-2

Cervical cancer

 

NF-kB [165]

let-7a-3/b

HeLa, 293T

 

ESE3/EHF [78]

let-7b

Prostate cancer

 

P53 [122]

let-7 a, b, c, e, f, g, i, Mir-98

Colon cancer

 

Tritetraspolin [123]

let-7b, f

Ovarian cancer

 

MAPK-Erk [120]

let-7a, g

Mouse embryonic carcinoma

 
  1. *Indirect by inducing promoter methylation