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Table 5 Let-7 regulators on transcriptional, post-transcriptional, and functional levels

From: Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Let-7 regulation
Inhibitor Family member Context Mechanism
JARID1B [91] let-7e Breast cancer  
p53 mutant [81] let-7i Lung cancer  
DCMAKL-1 [125] let-7a Colorectal cancer  
MYC [105] let-7a-1, f-1, d Hepatocellular carcinoma  
OCT-1 [156] let-7g Aorta smooth muscle cells  
COX2* [161] let-7b Urothelial cancer  
TWIST [106] let-7i Head and neck cancer  
BMI1 [106, 162] let-7i Head and neck cancer  
KDM2B [163] let-7b Embryonic fibroblasts Promoter methylation
LIN28 [110, 113, 133] let-7a1, a2, b, c, d, e, g, f1, f2, I, Mir-98 Mouse ESCs, Hela cells  
STAT3 [85] let-7a Ewing sarcoma NFkB activation
NFkB [119] let-7a, b, c, d, f Breast cancer LIN28 up-regulation
MiR-107 [126] let-7a Breast cancer  
LncRNA H19 [49] let-7a, b Breast cancer  
Link-ROR [127] let-7i, b, e, c Pancreatic cancer  
IMP2 [130] Seed Glioblastoma stem cells Target stabilization
LncRNA RSU1P2 [128] let-7a Cervical caner  
ADAR1 [124] let-7d Leukemia stem cells  
LncRNA CCR492 [129] Seed Mouse embryonic fibroblast  
eEBPa [164] let-7a2 Lung cancer  
SNP rs10877887 [107] let-7i Cervical cancer  
P53 [104] let-7a, b Colon cancer Cellular stress
Activator Family member Context  
ZEB1 [97] let-7e Esophageal cancer  
OCT4 [103] let-7a-2 Cervical cancer  
NF-kB [165] let-7a-3/b HeLa, 293T  
ESE3/EHF [78] let-7b Prostate cancer  
P53 [122] let-7 a, b, c, e, f, g, i, Mir-98 Colon cancer  
Tritetraspolin [123] let-7b, f Ovarian cancer  
MAPK-Erk [120] let-7a, g Mouse embryonic carcinoma  
  1. *Indirect by inducing promoter methylation