From: Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Let-7 regulation | |||
---|---|---|---|
Inhibitor | Family member | Context | Mechanism |
JARID1B [91] | let-7e | Breast cancer | Â |
p53 mutant [81] | let-7i | Lung cancer | Â |
DCMAKL-1 [125] | let-7a | Colorectal cancer | Â |
MYC [105] | let-7a-1, f-1, d | Hepatocellular carcinoma | Â |
OCT-1 [156] | let-7g | Aorta smooth muscle cells | Â |
COX2* [161] | let-7b | Urothelial cancer | Â |
TWIST [106] | let-7i | Head and neck cancer | Â |
let-7i | Head and neck cancer | Â | |
KDM2B [163] | let-7b | Embryonic fibroblasts | Promoter methylation |
let-7a1, a2, b, c, d, e, g, f1, f2, I, Mir-98 | Mouse ESCs, Hela cells | Â | |
STAT3 [85] | let-7a | Ewing sarcoma | NFkB activation |
NFkB [119] | let-7a, b, c, d, f | Breast cancer | LIN28 up-regulation |
MiR-107 [126] | let-7a | Breast cancer | Â |
LncRNA H19 [49] | let-7a, b | Breast cancer | Â |
Link-ROR [127] | let-7i, b, e, c | Pancreatic cancer | Â |
IMP2 [130] | Seed | Glioblastoma stem cells | Target stabilization |
LncRNA RSU1P2 [128] | let-7a | Cervical caner | Â |
ADAR1 [124] | let-7d | Leukemia stem cells | Â |
LncRNA CCR492 [129] | Seed | Mouse embryonic fibroblast | Â |
eEBPa [164] | let-7a2 | Lung cancer | Â |
SNP rs10877887 [107] | let-7i | Cervical cancer | Â |
P53 [104] | let-7a, b | Colon cancer | Cellular stress |
Activator | Family member | Context | Â |
---|---|---|---|
ZEB1 [97] | let-7e | Esophageal cancer | Â |
OCT4 [103] | let-7a-2 | Cervical cancer | Â |
NF-kB [165] | let-7a-3/b | HeLa, 293T | Â |
ESE3/EHF [78] | let-7b | Prostate cancer | Â |
P53 [122] | let-7 a, b, c, e, f, g, i, Mir-98 | Colon cancer | Â |
Tritetraspolin [123] | let-7b, f | Ovarian cancer | Â |
MAPK-Erk [120] | let-7a, g | Mouse embryonic carcinoma | Â |