Table 4 Validated and non-validated direct Let-7 targets

HMGA2 [39, 57, 67, 70, 89, 142]

Yes

TARBP2 [40, 81]

Yes

HMGA1 [81]

Yes

ZC3H3 [40, 81]

Yes

LIN28A [33, 69, 115]

Yes

Etv2 [143]

Yes

c-MYC [129, 144]

Yes

Acvr1b [145]

Yes

LIN28B [33, 81, 89]

Yes

Zbtb16 (PLZF) [146]

Yes

STAT3 [63, 85]

Yes

Cyclin D1 [64, 75]

Yes

N-RAS [72, 81, 147]

Yes

Cyclin A [75]

Yes

K-RAS [147]

Yes

IMP1 [65, 89]

Yes

H-RAS [57, 147]

Yes

MAP4K3 [44]

Yes

Dicer1 [100]

Yes

ITGB3 [44]

Yes

IL-6 [119]

Yes

HIF-1A [148]

Yes

Cyclin D [35, 91]

Yes

IGF2BP1 [144, 149]

Yes

IGF1 [150]

Yes

IGF2BP2 [151]

Yes

ARID3A [97]

Yes

RSU1P2 [128]

Yes

ARID3B [80]

Yes

NEDD9 [106]

Yes

TCF-4^a [60]

Yes

DOCK3 [106]

Yes

MMP1 [152]

Yes

NGF [153]

Yes

NTN1 [154]

Yes

GHR [155]

Yes

INSR [115]

Yes

Twist [62]

No

IGF1R [115, 150]

Yes

Snai1 [62]

No

IRS2 [115]

Yes

Vimentin [62]

No

Pik3ip1 [115]

Yes

N-Cadherin [62]

No

AKT2 [115]

Yes

IMP2 [89]

No

TSC1 [115]

Yes

ATXN7L3 [93]

No

RICTOR [115]

Yes

USP44 [93]

No

LOX1 [156]

Yes

USP42 [93]

No

PBX3 [71]

Yes

BCL11A [157]

No

ERα [40]

Yes

TGF-βR1 [158]

No

EZH2 [35, 139]

Yes

TGF-βR3 [158]

No

E2F2 [40, 73, 81]

Yes

SMAD2 [158]

No

E2F5 [81]

Yes

FIGN [89]

No

CPSF1 [40, 81]

Yes

CDC34 [89]

No

DDX18 [40, 81]

Yes

NME6 [89]

No

EiF4A1 [40, 81]

Yes

MED6 [89]

No

EiF2C2^b [40, 81]

Yes

COL4A5 [89]

No

LSM6 [40, 81]

Yes

NAP1L1 [89]

No

PABPC4 [40, 81]

Yes

PIGA [89]

No

RBM38 [40, 81]

Yes

SLC25A24 [89]

No

PLAGL2 [159]

Yes

E2F1 [37]

No

AURKB [160]

Yes

E2F1 [37]

No

PLAGL2 [159]

Yes