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Table 4 Validated and non-validated direct Let-7 targets

From: Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Human let-7 targets Validated Human let-7 targets Validated
HMGA2 [39, 57, 67, 70, 89, 142] Yes TARBP2 [40, 81] Yes
HMGA1 [81] Yes ZC3H3 [40, 81] Yes
LIN28A [33, 69, 115] Yes Etv2 [143] Yes
c-MYC [129, 144] Yes Acvr1b [145] Yes
LIN28B [33, 81, 89] Yes Zbtb16 (PLZF) [146] Yes
STAT3 [63, 85] Yes Cyclin D1 [64, 75] Yes
N-RAS [72, 81, 147] Yes Cyclin A [75] Yes
K-RAS [147] Yes IMP1 [65, 89] Yes
H-RAS [57, 147] Yes MAP4K3 [44] Yes
Dicer1 [100] Yes ITGB3 [44] Yes
IL-6 [119] Yes HIF-1A [148] Yes
Cyclin D [35, 91] Yes IGF2BP1 [144, 149] Yes
IGF1 [150] Yes IGF2BP2 [151] Yes
ARID3A [97] Yes RSU1P2 [128] Yes
ARID3B [80] Yes NEDD9 [106] Yes
TCF-4a [60] Yes DOCK3 [106] Yes
MMP1 [152] Yes NGF [153] Yes
NTN1 [154] Yes GHR [155] Yes
INSR [115] Yes Twist [62] No
IGF1R [115, 150] Yes Snai1 [62] No
IRS2 [115] Yes Vimentin [62] No
Pik3ip1 [115] Yes N-Cadherin [62] No
AKT2 [115] Yes IMP2 [89] No
TSC1 [115] Yes ATXN7L3 [93] No
RICTOR [115] Yes USP44 [93] No
LOX1 [156] Yes USP42 [93] No
PBX3 [71] Yes BCL11A [157] No
ERα [40] Yes TGF-βR1 [158] No
EZH2 [35, 139] Yes TGF-βR3 [158] No
E2F2 [40, 73, 81] Yes SMAD2 [158] No
E2F5 [81] Yes FIGN [89] No
CPSF1 [40, 81] Yes CDC34 [89] No
DDX18 [40, 81] Yes NME6 [89] No
EiF4A1 [40, 81] Yes MED6 [89] No
EiF2C2b [40, 81] Yes COL4A5 [89] No
LSM6 [40, 81] Yes NAP1L1 [89] No
PABPC4 [40, 81] Yes PIGA [89] No
RBM38 [40, 81] Yes SLC25A24 [89] No
PLAGL2 [159] Yes E2F1 [37] No
AURKB [160] Yes E2F1 [37] No
PLAGL2 [159] Yes   
  1. aLet-7 inhibits at the promoter region
  2. bLet-7 increases expression