Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Clinical and Translational Medicine

Table 2 Levels of let-7 family members relative to normal tissue in different types of human cancer

Let-7 expression in tumors
Let-7	Decreased	Increased
Let-7a	Hepatoblastoma [70] Glioma [67] Ewing sarcoma [85] Gastric [48] Nasopharyngeal [70] Lung [47] Liver [42, 96] Melanoma [75] Endometrial [137] Cervical [107, 128] Prostate [138, 139] Ovarian [43]
Let-7b	Hepatoblastoma [66] Liver [42, 96] Melanoma [75] Prostate [138, 139]	Ovarian [43]
Let-7c	Prostate [58, 139] Acute promyelocitic leukemia [31] Liver [42, 96] Lung [44] Endometrial [137] Prostate [138]	Ovarian [43]
Let-7d	Oral [62] Liver [42] Melanoma [75] Prostate [138] Ovarian [140]	Acute promyelocytic leukemia [31]
Let-7e	Melanoma [75] Endometrial [137] Prostate [138] Ovarian [140]	Tongue [99] Esophageal [97]
Let-7f	Liver [42] Endometrial [137] Prostate [138] Ovarian [43, 140]	Tongue [99]
Let-7 g	HCC [42] Prostate [138] Ovarian [43]
Let-7i	Tongue [99] Ovarian [141] Melanoma [75] Cervical [107]
Mir-98	Glioma [71] Salivary adenoid cystic carcinoma [72] Prostate [138]	Ovarian [100]