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Table 1 Shared immunoglobulin heavy and light chain CDR3 variants in monocytes and TAM from 15 glioblastoma patients

From: Circulating monocytes and tumor-associated macrophages express recombined immunoglobulins in glioblastoma patients

CDR3 GBM001 GBM002 GBM003 GBM004 GBM005 GBM006 GBM0007 GBM008 GBM009 GBM010 GBM011 GBM012 GBM013 GBM014 GBM015
TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood TAM Blood
Shared immunoglobulin heavy chains
VRSWAYSLTPAGTGTYYFES   X X                            
GRGGTGYYYYMDV    X X                           
ARGAGVRYFDWLSPAGY    X   X X                         
ARVPINYDILTGTDY      X X                         
ARDEKQLVRNYYYYYGMDV                 X X        X       
AKTLMVRGVRNAFDI                        X   X X     
AGEGSVVLTTSTFDI                        X X       X
ARDWRSGGSCYYY                        X X       
Shared immunoglobulin light chains
HQSSNLPWT X    X                           
IRVVIYLGR X    X          X X   X    X    X         
MQGTHWPPTWT X X   X    X         X                
QQYYRIPCT   X X                            
QHYNNWPWT          X            X   X         
QHYNDWPWT          X          X             
QHYNAWPPWT           X         X             
NTIMPGLRGR           X         X             
QQSYSTPLT                 X           X     
QAWDSSTAV                            X X   
  1. Shown are the shared immunoglobulin heavy (n = 8) and light chain (n = 10) CDR3 variants of monocytes and TAM from 15 glioblastoma patients. The CDR3 sequences were marked with an “X” in the respective cell preparations. Shared CDR3 variants were found between different glioblastoma patients (inter-individual sharing) and between the monocyte and TAM preparations of single glioblastoma patients (intra-individual sharing)