Fig. 4

In vivo small-animal SPECT/CT imaging of MMP activation. a–c Examples of coronal (left) and transversal (right) views of fused small-animal SPECT/CT images of WT mice injected with RP805 (a) and CC10-IL-13 Tg mice injected with RP805 (b) or its control, amide analog tracer (c). d Small-animal SPECT–derived quantification tracer uptake in lungs. N = 5, 6, 13, and 5, respectively, for WT mice injected with RP805 and CC10-IL-13 Tg mice injected with RP805 or amide, control analog. *P, 0.01. **P, 0.001. cpv 5 counts per voxel; ID 5 injected dose. (This research was originally published in JNM [32]. © by the Society of Nuclear Medicine and Molecular Imaging, Inc.)