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Fig. 3 | Clinical and Translational Medicine

Fig. 3

From: Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection

Fig. 3

FABP5-deficiency increases CS- and P. aeruginosa-induced pulmonary inflammation. After 5 days of CS exposure, mice were infected with P. aeruginosa and harvested 16 h post infection. A Hematoxylin and eosin stained paraffin sections of lungs from WT and FABP5−/− mice. Bars represent 50 µm. Insert: Higher magnification. B Lung tissue histopathology score of WT or FABP5−/− mice. C Total leukocytes, macrophages and neutrophils in the bronchoalveolar lavage (BAL) of WT and FABP5−/− mice. D IL-6 and KC protein levels in the BAL of WT and FABP5−/− mice exposed to filtered air or CS 16 h post infection. Data are representative of three independent experiments and represent the mean ± SEM. n = 4–6 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001

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