Fig. 1
From: Combination therapy to checkmate Glioblastoma: clinical challenges and advances
Schematic representation of combination therapy in treatment of GBM. Targeted therapy approaches have the potential to improve patient outcome in the treatment of Glioblastoma. Small-molecule inhibitors in combination with chemo/radiotherapy can overcome chemo/radioresistance in patients improving treatment efficacy when compared to monotherapy. We summarize small molecule inhibitors and their gene targets that are in preclinical development for GBM therapy and are being tested in combination with radio- and/or chemotherapy