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Fig. 4 | Clinical and Translational Medicine

Fig. 4

From: Cytokines, breast cancer stem cells (BCSCs) and chemoresistance

Fig. 4

The interplay of cytokines and BCSCs on regulating chemotherapeutic resistance. Under the stress of chemotherapeutic drugs, a variety of different sources of cytokines can regulate the self-renewal and promote the survival of BCSCs, leading to drug resistance. Cytokines are a convenient “bridge” between BCSCs and chemoresistance (left panel). If the regulatory signaling to BCSCs is interfered by cytokine blockade, the support of cytokine signals for BCSC chemo-resistance will be broken, increasing the sensitivity of breast cancer chemotherapy (right panel)

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