Table 1 Melanoma Pathology (Proposed by Mool and Krausz)
SSM | NM | LMM | ALM | |
|---|---|---|---|---|
Peak incidence | Middle adult life | Middle adult life | Late adult life | Late adult life |
Race | Usually whites | Usually whites | Only whites | All races |
Localization | All skin | All skin | Sun-damaged skin | Palms, Soles, Subungual |
Main cell type in epidermis | Epithelioid | Epithelioid | Dendritic | Dendritic |
Pagetoid lateral spread | Usual | Absent and minimal | Rare | Rare |
Lentiginous lateral spread | Uncommon | Absent | Usual | Usual |
Epidermal hyperplasia | Often | Sometimes | Absent | Present |
Epidermal atrophy | Sometimes | Sometimes | Present | Absent |
Actinic damage of skin | Sometimes | Sometimes | Present | Absent |
Relative frequencies (Clark et al. [12]) unclassifiable: 10% | 67% | 10% | 9% | 4% |