Fig. 6From: Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanismsA hypothetical model of CAF-mediated YAP activation in cancer cells via ECM remodeling. On the first step soluble factors secreted by cancer cells activate YAP in CAFs, leading to ECM remodeling and stiffening. Stiff and fibronectin-rich ECM would promote YAP activation in both CAFs and cancer cells, which confers therapy resistance of cancerBack to article page