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Clinical and Translational Medicine

Table 1 A subset of EVARDS has mesenchymal stem cell (MSC)-origin and shows significant increase in the ARDS subjects compared to controls

From: Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome

Variable

(EVs/μl)

Mean

Fold increase

EVCtrl

EVARDS

Alk5

3446 (40%)

7200 (53%)

2.1

Alk5/CD73

53 (0.6%)

294 (2.1%)

5.6

Alk5/CD105

478 (5.5%)

1008 (7.4%)

2.1

Alk5/CD62

632 (7.3%)

1021 (7.5%)

1.6

Alk5/CD68

534 (6.2%)

1123 (8.2%)

2.1

Alk5/CD31

432 (5.0%)

782 (5.7%)

1.8

Alk5/CD73/CD105

49 (0.57%)

234 (1.7%)

4.8

  1. Mean numbers/percentages of EVCtrl and EVARDS co-labeled with allophycocyanin (APC)-Alk5, phycoerythrin (PE) and pacific blue-conjugated cell surface markers. We used CD62 for platelets [59], CD68 as monocytes/macrophage markers [60, 61], CD31 for ECs [62, 63] and CD73 and CD105 for MSCs [32]. Isotype matched Abs served as control; n = 7 EVs isolates/experimental condition, in three independent experiments
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