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Clinical and Translational Medicine
Fig. 6 | Clinical and Translational Medicine

Fig. 6

From: Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome

Fig. 6

EVARDSAlk5Runx1p66 improve the interendothelial junctional integrity of LPS-treated ECs. Representative VE-cadherin/Alexa Fluor 488 staining of ECCtrl (a), ECs treated with 1 μg/ml LPS (ECLPS) for 6 h (b) and 30 h (c); ECLPS (6 h) were treated for 30 h with either (d) 1.6 × 103 EVARDSRunx1p66/1 ml growth media or (e) 1.6 × 103 EVARDSRunx1p52/1 ml growth media (non-surviving ARDS patient). Bars: 15 μm (a–e). f Morphometric analysis of the interendothelial gap area. All data labels are included for each bar. n = 3 EVs preparations/experimental condition, in three independent experiments; *p < 0.01; p** < 0.05

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