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Clinical and Translational Medicine
Fig. 8 | Clinical and Translational Medicine

Fig. 8

From: Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Fig. 8

The effect of fibrinolytic therapy on concentrations of d-dimers in BAL of Groups 1 and 2. The concentration of d-dimer in BAL of ISIALI sheep after fibrinolytic therapy was measured using a sheep d-dimer (D2D) ELISA Kit (MyBioSource, CA) as described in “Methods”. Sheep with induced smoke ALI was treated with nebulized scuPA (4 mg) or tPA (4 mg) (Gr1, TRX) and scuPA (4 mg or 8 mg) or tPA (4 mg) (GR2 TRX) or vehicle control (Gr1, NSS and Gr2, NSS). BAL (Gr1: 5 saline-controls, GR1 TRX: 11 scuPA and tPA treated animals; Gr2: 6 saline controls, 5 and 7 animals treated with 4 and 8 mg of nebulized scuPA respectively, and 5 animals treated with 4 mg nebulized tPA) was collected at 48 h after the initiation of ISIALI as described in Fig. 1 and then analyzed [23]. Data are presented as box plots (showing interquartile ranges). No statistical significant difference was observed in the median values of d-dimer between treatment groups

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