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Clinical and Translational Medicine
Fig. 5 | Clinical and Translational Medicine

Fig. 5

From: Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Fig. 5

SCMV ventilation with limited suctioning and increased in a dose of plasminogen activator improved BAL PA delivery. a, b Changes in the ventilation strategy Group 2 (Gr2) vs Group 1 (Gr1) and an increase in the dose of the tPA (triangles) or scuPA (squares) from 4 to 8 mg resulted in an increase in BAL plasminogen activator (PA); human uPA or tPA activity (a) and antigen (b) after 48 h of treatment. Data are presented as box plots (showing interquartile ranges). Total antigen increases significantly (p < 0.001) overall as ventilation strategy changes from Gr1 at 4 mg through Gr2 at 4 mg to Gr2 at 8 mg. Pair-wise, the differences in median was profound only between Gr1 at 4 mg and Gr2 at 8 mg (p = 0.02). No statistically significant difference in the median of these parameters were noted between Gr1 and Gr2 at 4 mg. There was no statistically significant difference between levels of PA activity between the groups

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