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Clinical and Translational Medicine
Fig. 4 | Clinical and Translational Medicine

Fig. 4

From: Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Fig. 4

Pathophysiologic effects observed in Group 2 sheep treated with nebulized scuPA. Data from saline vehicle nebulized controls (n = 9) and from sheep treated with nebulized scuPA at the 4 mg (n = 5, including one animal that died prematurely) and 8 mg (n = 8, including one animal which died prior to 48 h) (Fig. 1). a PaO2: arterial oxygen tension (mmHg): no significant differences between dosing levels and control. b PaO2/FiO2 ratios: statistically significant increase for dosing at 8 mg compared to control (p = 0.02), independent of time; but no significant difference at 4 mg dosing. c Peak airway pressures (cmH2O) and d plateau airway pressures (cmH2O) were significantly reduced compared to controls over time (p < 0.001) at 8 mg and 4 mg scuPA. The asterisk in d shows a significant reduction of plateau pressures in the scuPA 8 mg group versus controls at the 48 h interval. e Static lung compliance (mL/cmH2O/kg) was greater compared with control overtime (p < 0.001), with scuPA 4 mg and scuPA 8 mg (p = 0.02 in each case) treated groups greater than control, independent of time. f Lung resistance (L/cmH2O/min) was significantly decrease compared to control overtime (p < 0.001), with scuPA 4 mg (p = 0.01) and scuPA 8 mg (p = 0.02) treated groups, independent of time. All depicted trends were statistically significant over time (p < 0.001). Statistical significance of treatment groups against controls is shown by solid (scuPA, 4 mg) or dashed (scuPA, 8 mg) brackets

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