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Clinical and Translational Medicine
Fig. 3 | Clinical and Translational Medicine

Fig. 3

From: Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Fig. 3

Pathophysiologic effects observed in Group 2 sheep treated with nebulized tPA. Data from saline vehicle nebulized controls (n = 9, including two animals that succumbed prematurely, prior to 48 h) or animals nebulized with tPA at the 2 mg dose according to the schedule illustrated in Fig. 1 (n = 2) or at the 4 mg/unit dose (n = 6, including one animal that succumbed prematurely) or at 8 mg (n = 2). a PaO2: arterial oxygen tension (mm Hg). b PaO2/FiO2 ratios. c Peak airway pressures (cmH2O). d Plateau airway pressures (cmH2O). e Static lung compliance (mL/cmH2O/kg). f Lung resistance (L/cmH2O/min). Although all the above trend over time were statistically significant (p < 0.001) there were no statistically significant intergroup differences

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