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Clinical and Translational Medicine
Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin–EGFR crosstalk

Fig. 2

E-Cadherin/catenin–PI3K/AKT crosstalk. Release of negative feedback inhibition of PI3K/AKT signaling via reduced PTEN expression through elevated nuclear β-catenin levels. Disruption of the E-cadherin/catenin complex induces nuclear translocation of β-catenin repressing Egr-1-mediated PTEN expression leading to increased AKT activation

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