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Clinical and Translational Medicine
Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: Merging perspectives: genotype-directed molecular therapy for hereditary diffuse gastric cancer (HDGC) and E-cadherin–EGFR crosstalk

Fig. 1

Bidirectional E-cadherin/catenin–EGFR cross talk in epithelial biology. Protein–protein interaction with the extracellular cadherin-binding domains of E-cadherin inhibits ligand-mediated activation of EGFR signaling (right); loss of E-cadherin–EGFR interaction leads to increased activation of PI3K, c-Src, and MAPK kinase pathway activation and phosphorylation and destabilization of the E-cadherin/catenin complex (left)

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