The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

Urabe, Fumihiko; Kosaka, Nobuyoshi; Yoshioka, Yusuke; Egawa, Shin; Ochiya, Takahiro

doi:10.1186/s40169-017-0176-z

Clinical and Translational Medicine

Table 1 miRNAs in EVs in cancer microenvironment

From: The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

Category	Function	miRNAs	Target genes	EV producing cells	Recipient cells	Refs.
Inducing angiogenesis and endothelial cell permeability	Enhancement of angiogenesis	miR-9-5p	SOCS5	Melanoma cells	Endothelial cells	[24]
	Enhancement of angiogenesis	miR-210-3p	EFNA3	Lung cancer cells	Endothelial cells	[25, 26]
	Enhancement of angiogenesis and vascular permeability	miR-23a-3p	PHD 1 and 2, ZO-1	Lung cancer cells	Endothellial cells	[27]
	Destruction of BBB	miR-105-5p	ZO-1	Breast cancer cells	Endothelial cells (distant site)	[32]
	Destruction of BBB	miR-181c-5p	PDPK1	Breast cancer cells	Endothelial cells (distant site)	[33]
Crosstalk between cancer cells and stromal fibroblasts	Induction of CAFs	miR-155-5p	TP53INP1	Pancreastic cancer cells	Fibroblasts	[40]
	Suppression of apoptosis and confering chemoresistance	miR-21-5p	AFAP1	CAFs and CAAs	Breast cancer cells	[41]
	Stemness and EMT	miR-21-5p, miR-378e and miR-143-3p	Not mentioned	CAFs	Breast cancer cells	[42]
	Induction of CAFs	miR-9-5p	Not mentioned	Breast cancer cells	Fibroblasts	[43]
	Development of premetastatic niche	miR-494 and miR-542-3p	CDH17	Metastatic rat pancreatic adenocarcinoma	Lymph node stromal cells and lung fibroblasts (distant site)	[44]
	Development of premetastatic niche	miR-122-5p	PKM2, CS	Breast cancer cells	Astrocytes and lung fibroblasts (distant site)	[45]
Modulation of immune system	Induction of TAMs	miR-21-5p and miR-29a-3p	Directly bind to TLR family (murine TLR7 and human TRL8)	Lung cancer cells	Murine macrophages	[53]
Modulation of immune system	Induction of TAMs	miR-222-3p	SOCS3	EOC cells	Monocytes	[54]
Regulation of cancer cell proliferation and drug resistance	Supression of cancer cell proliferation (competition during cancer initiation)	miR-143-3p	KRAS and ERK5	Normal prostate epithelial cells	Prostate cancer cells	[16]
	Promoting MET	miR-200 family	ZEB2, SEC23A	Highly metastatic lung cancer cells	Weakly metastatic lung cancer cells	[61]
	Promoting invasiveness	miR-10b-5p	HOXD10	Metastatic breast cancer cells	Non-malignant breast epithelial cells	[62]
	Adriamycin and docetaxel resistance	miR-30a-5p, miR-100-5p and miR-222-3p	PTEN (miR-222)	Drug resistant breast cancer cells	Drug sensitive breast cancer cells	[64]
	Gemcitabine resitance	miR-222-3p	SOCS3	Drug resistant NSCLC cells	Drug sensitive NSCLC cells	[65]
	Activating monocytes	miR-21-5p	Directly bind to TRL8	Neuroblastoma cells	Human monocytes	[66]
	Cisplatin resistance	miR-155-5p	TERF1	Activated monocytes	Neuroblastoma cells	[66]
	Induction of dormant state (long-term recurrecnce)	miR-23b-3p	MARCKS	BM–MSCs	Breast cancer cells	[68]

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