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Clinical and Translational Medicine

Table 1 miRNAs in EVs in cancer microenvironment

From: The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

Category Function miRNAs Target genes EV producing cells Recipient cells Refs.
Inducing angiogenesis and endothelial cell permeability Enhancement of angiogenesis miR-9-5p SOCS5 Melanoma cells Endothelial cells [24]
Enhancement of angiogenesis miR-210-3p EFNA3 Lung cancer cells Endothelial cells [25, 26]
Enhancement of angiogenesis and vascular permeability miR-23a-3p PHD 1 and 2, ZO-1 Lung cancer cells Endothellial cells [27]
Destruction of BBB miR-105-5p ZO-1 Breast cancer cells Endothelial cells (distant site) [32]
Destruction of BBB miR-181c-5p PDPK1 Breast cancer cells Endothelial cells (distant site) [33]
Crosstalk between cancer cells and stromal fibroblasts Induction of CAFs miR-155-5p TP53INP1 Pancreastic cancer cells Fibroblasts [40]
Suppression of apoptosis and confering chemoresistance miR-21-5p AFAP1 CAFs and CAAs Breast cancer cells [41]
Stemness and EMT miR-21-5p, miR-378e and miR-143-3p Not mentioned CAFs Breast cancer cells [42]
Induction of CAFs miR-9-5p Not mentioned Breast cancer cells Fibroblasts [43]
Development of premetastatic niche miR-494 and miR-542-3p CDH17 Metastatic rat pancreatic adenocarcinoma Lymph node stromal cells and lung fibroblasts (distant site) [44]
Development of premetastatic niche miR-122-5p PKM2, CS Breast cancer cells Astrocytes and lung fibroblasts (distant site) [45]
Modulation of immune system Induction of TAMs miR-21-5p and miR-29a-3p Directly bind to TLR family (murine TLR7 and human TRL8) Lung cancer cells Murine macrophages [53]
Induction of TAMs miR-222-3p SOCS3 EOC cells Monocytes [54]
Regulation of cancer cell proliferation and drug resistance Supression of cancer cell proliferation (competition during cancer initiation) miR-143-3p KRAS and ERK5 Normal prostate epithelial cells Prostate cancer cells [16]
Promoting MET miR-200 family ZEB2, SEC23A Highly metastatic lung cancer cells Weakly metastatic lung cancer cells [61]
Promoting invasiveness miR-10b-5p HOXD10 Metastatic breast cancer cells Non-malignant breast epithelial cells [62]
Adriamycin and docetaxel resistance miR-30a-5p, miR-100-5p and miR-222-3p PTEN (miR-222) Drug resistant breast cancer cells Drug sensitive breast cancer cells [64]
Gemcitabine resitance miR-222-3p SOCS3 Drug resistant NSCLC cells Drug sensitive NSCLC cells [65]
Activating monocytes miR-21-5p Directly bind to TRL8 Neuroblastoma cells Human monocytes [66]
Cisplatin resistance miR-155-5p TERF1 Activated monocytes Neuroblastoma cells [66]
Induction of dormant state (long-term recurrecnce) miR-23b-3p MARCKS BM–MSCs Breast cancer cells [68]
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